The year 2021 marks the 10th anniversary of Journal of Clinical Medicine, and as one of the major sections of JCM, we are launching a 10th anniversary Special Issue in the section “Gastroenterology & Hepatopancreatobiliary Medicine”. We accepted papers for the Special Issue, titled "Recent diagnostic and therapeutic advance in Gastroenterology & Hepatopancreatobiliary Medicine". This medical field is a complex and wide-ranging field that deals with diseases in multiple organs such as the gastrointestinal tract and hepatobiliary pancreas. With recent advances in diagnostic imaging and interventional treatment, those in endoscopic diagnosis and treatment, those in functional test and those in genetic diagnosis and drug therapy, including the molecular-targeted therapy, many new medical findings have been accumulated. In this Special Issue, we looked for reports that make full use of advances in diagnostics and therapeutics in the field of Gastroenterology and Hepatopancreatobiliary Medicine.

Listed by Unglue.it.

Gonorrhea is a sexually transmitted infection caused by the obligate human pathogen“Neisseria gonorrhoeae”. This Gram-negative diplococcus is highly infective due to its virulence factors: pili, Por proteins, Opa proteins, Rmp proteins, lipooligosaccharides and IgA protease. Despite existing guidelines for its treatment, the incidence of the disease follows an increasing trend worldwide. This is mainly due to the appearance of antibiotic-resistant strains, inefficient diagnostic methods and poor sexual education. Without an effective vaccine available, the key priorities for the control of the disease include sexual education, contact notification, epidemiological surveillance, diagnosis and effective antibiotic treatment. This Special Issue focuses on some of these important issuesm such as the molecular mechanisms of the disease, diagnostic tests and different treatment strategies used to combat gonorrhea.

Listed by Unglue.it.

A significant increase in the prevalence of campylobacteriosis cases has been observed over the past years. Campylobacter has emerged as the leading cause of bacterial foodborne disease worldwide with a significant impact on human health and an associated economic burdens. Campylobacteriosis human cases have been generally correlated with the handling, preparation and consumption of poultry. In 2017, the European Commission regulation has amended Regulation (EC) No 2073/2005 on the hygiene of foodstuffs as regards Campylobacter on broiler carcasses stating a limit of 1000 cfu/g. Campylobacter is also present in other farm animals and is frequently found on a range of foodstuffs due to cross contamination. Among the pathogenic species, C. jejuni is the most prevalent species followed by C. coli. Current guidelines highlight the importance of biosecurity but these measures are failing to mitigate the risk of pathogenic Campylobacter. As an obligate microaerophile, Campylobacter does not multiply under atmospheric oxygen concentration at ambient temperatures. It therefore constitutes a puzzle as to how it can survive from farm to retail outlets. The underlying molecular mechanisms of persistence, survival and pathogenesis appear to be unique to this pathogen. Recent research has indicated how genomic polymorphism, restricted catabolic capacity, self regulation or deregulation of genes, bacterial cooperation and unknown contamination routes may be connected to this specificity.This book includes original studies on both C. jejuni and C. coli species dealing with epidemiology and animal carriage, host interaction, control strategies, metabolism and regulation specificities of these two pathogenic species, methodology to improve cultural techniques and chicken gut microbiota challenged with Campylobacter.

Listed by Unglue.it.

The International Symposium on Humanities and Social Sciences: Addressing Global Challenges-Exploring Socio-Cultural Dynamics and Sustainable Solutions in a Changing World (ISHSS 2023) unfolds as a crucial academic undertaking, centred around the overarching theme of intellectual synergy and inquiry. This conference serves as a vibrant forum, facilitating discussions on a wide array of subjects within the realms of humanities and social sciences. The curated collection of proceedings encapsulates an expansive spectrum of subject areas, transcending disciplinary boundaries to encapsulate sociology, anthropology, history, and beyond. The significance of this compilation lies not only in the wealth of knowledge it imparts but also in its potential to resonate with a diverse audience. From academicians to practitioners, the discourse transcends traditional boundaries, offering insights that cater to the intellectual curiosity of a broad audience. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license.

Listed by Unglue.it.

The book presents several studies reporting advances on melanoma pathogenesis, diagnosis and therapy. It represents a milestone on the state of the art, updated at 2021, and also presents the current knowledge on the future developments in melanoma field.

Listed by Unglue.it.

This reprint focuses on novel findings of diagnostic dermatopathology, such as diagnosable new morphological (histopathologic) findings, immunohistochemical and immunofluorescent markers, and molecular techniques. Dermatopathology is the most sophisticated area in anatomic pathology; we can easily observe superficial skin lesions using our eyes without the need for an invasive approach and can easily compare gross configurations to microscopic and immunohistochemical findings. Meanwhile, dermatopathology has recently focused on the study of various cutaneous diseases at the molecular biology level. Many cutaneous diseases are now being well-researched, and special attention is paid to keratoacanthoma, lichen sclerosus (et atrophicus), mycosis fungoides, atopic dermatitis, epidermolysis bullosa, extramammary Paget’s disease, malignant melanoma, psoriasis, and secondary neoplasms associated with nevus sebaceous.

Listed by Unglue.it.

One of the most popular and most quoted books in English, Alice's Adventures in Wonderland was the creation of Charles Lutwidge Dodgson (1832–1898), a distinguished scholar, mathematician and author who wrote under the pseudonym of Lewis Carroll. Written for young readers but enjoyed equally by adults, the fantastic tale transformed children's literature, liberating it from didactic constraints. The story is deeply but gently satiric, enlivened with an imaginative plot and brilliant use of nonsense, as it relates Alice's adventures in a bizarre, topsy-turvey land underground. There she encounters a cast of strange characters and fanciful beasts, including the White Rabbit, March Hare, and Mad Hatter, the sleepy Dormouse and grinning Cheshire Cat,the Mock Turtle, the dreadful Queen of Hearts, and unusual creatures. ---------- Also contained in: - [Alice in Wonderland](https://openlibrary.org/works/OL151449W) - [Alice's Adventures in Wonderland / The Hunting of the Snark](https://openlibrary.org/works/OL17727149W) - [Alice's Adventures in Wonderland / Through the Looking Glass](https://openlibrary.org/works/OL9770557W) - [Alice's Adventures in Wonderland / Through the Looking-Glass / Hunting of the Snark](https://openlibrary.org/works/OL8029136W) - [Best of Lewis Carroll](https://openlibrary.org/works/OL138061W) - [Complete Illustrated Works of Lewis Carroll](https://openlibrary.org/works/OL151414W) - [Complete Stories of Lewis Carroll](https://openlibrary.org/works/OL24036293W) - [Complete Works of Lewis Carroll](https://openlibrary.org/works/OL151444W) - [Magic in the Air](https://openlibrary.org/works/OL1387662W) - [Reader's Digest Best Loved Books for Young Readers: Volume Eight](https://openlibrary.org/works/OL15150278W)

Listed by Unglue.it.

One of the most popular and most quoted books in English, Alice's Adventures in Wonderland was the creation of Charles Lutwidge Dodgson (1832–1898), a distinguished scholar, mathematician and author who wrote under the pseudonym of Lewis Carroll. Written for young readers but enjoyed equally by adults, the fantastic tale transformed children's literature, liberating it from didactic constraints. The story is deeply but gently satiric, enlivened with an imaginative plot and brilliant use of nonsense, as it relates Alice's adventures in a bizarre, topsy-turvey land underground. There she encounters a cast of strange characters and fanciful beasts, including the White Rabbit, March Hare, and Mad Hatter, the sleepy Dormouse and grinning Cheshire Cat,the Mock Turtle, the dreadful Queen of Hearts, and unusual creatures. ---------- Also contained in: - [Alice in Wonderland](https://openlibrary.org/works/OL151449W) - [Alice's Adventures in Wonderland / The Hunting of the Snark](https://openlibrary.org/works/OL17727149W) - [Alice's Adventures in Wonderland / Through the Looking Glass](https://openlibrary.org/works/OL9770557W) - [Alice's Adventures in Wonderland / Through the Looking-Glass / Hunting of the Snark](https://openlibrary.org/works/OL8029136W) - [Best of Lewis Carroll](https://openlibrary.org/works/OL138061W) - [Complete Illustrated Works of Lewis Carroll](https://openlibrary.org/works/OL151414W) - [Complete Stories of Lewis Carroll](https://openlibrary.org/works/OL24036293W) - [Complete Works of Lewis Carroll](https://openlibrary.org/works/OL151444W) - [Magic in the Air](https://openlibrary.org/works/OL1387662W) - [Reader's Digest Best Loved Books for Young Readers: Volume Eight](https://openlibrary.org/works/OL15150278W)

Listed by Unglue.it.

One of the most popular and most quoted books in English, Alice's Adventures in Wonderland was the creation of Charles Lutwidge Dodgson (1832–1898), a distinguished scholar, mathematician and author who wrote under the pseudonym of Lewis Carroll. Written for young readers but enjoyed equally by adults, the fantastic tale transformed children's literature, liberating it from didactic constraints. The story is deeply but gently satiric, enlivened with an imaginative plot and brilliant use of nonsense, as it relates Alice's adventures in a bizarre, topsy-turvey land underground. There she encounters a cast of strange characters and fanciful beasts, including the White Rabbit, March Hare, and Mad Hatter, the sleepy Dormouse and grinning Cheshire Cat,the Mock Turtle, the dreadful Queen of Hearts, and unusual creatures. ---------- Also contained in: - [Alice in Wonderland](https://openlibrary.org/works/OL151449W) - [Alice's Adventures in Wonderland / The Hunting of the Snark](https://openlibrary.org/works/OL17727149W) - [Alice's Adventures in Wonderland / Through the Looking Glass](https://openlibrary.org/works/OL9770557W) - [Alice's Adventures in Wonderland / Through the Looking-Glass / Hunting of the Snark](https://openlibrary.org/works/OL8029136W) - [Best of Lewis Carroll](https://openlibrary.org/works/OL138061W) - [Complete Illustrated Works of Lewis Carroll](https://openlibrary.org/works/OL151414W) - [Complete Stories of Lewis Carroll](https://openlibrary.org/works/OL24036293W) - [Complete Works of Lewis Carroll](https://openlibrary.org/works/OL151444W) - [Magic in the Air](https://openlibrary.org/works/OL1387662W) - [Reader's Digest Best Loved Books for Young Readers: Volume Eight](https://openlibrary.org/works/OL15150278W)

Listed by Unglue.it.

The book collects scientific contributions aiming at describing the common mechanism, across living species, by which innate immunity interacts with nanomaterials with the goal of harnessing such interactions for improving environmental and human safety and exploiting them for modulating immunity in vaccination strategies.

Listed by Unglue.it.

Medicinal plants and natural products have played a central role in therapeutics, being considered the origin of Pharmacy and Pharmacology. Plants are still a source in nature to obtain and isolate molecules with pharmacological applications (drug discovery), but can also be used as herbal medicinal products in traditional or complementary medicine.In addition, the WHO has launched a Traditional Medicine Strategy (2014–2023), including herbal medicines as medicinal therapies, with the aim to ensure the quality, safety, proper use, and effectiveness of traditional medicines, among other objectives.This is a reprint of articles from the Special Issue on “Bioactivity of Medicinal Plants and Extracts” published online in the open access journal Biology. This reprint includes a collection of original research and review articles on new advances in the development and application of bioactive compounds and extracts from plant matrices.

Listed by Unglue.it.

The authors in this volume explore the interconnected issues of intergenerational trauma and traumatic memory in societies with a history of collective violence across the globe. Each chapter's discussion offers a critical reflection on historical trauma and its repercussions, and how memory can be used as a basis for dialogue and transformation. The perspectives include, among others: the healing journey of three generations of a family of Holocaust survivors and their dialogue with third generation German students over time; traumatic memories of the British concentration camps in South Africa; reparations and reconciliation in the context of the historical trauma of Aboriginal Australians; and the use of the arts as a strategy of dialogue and transformation.
This book is made open access as part of the Knowledge Unlatched KU Select 2018: HSS Backlist Books

Listed by Unglue.it.

The business model concept has gained a prominent position both in academia and among practitioners during the past 30+ years. The aim of this Special Issue of Systems is to contribute to a stronger theoretical basis for the business model concept. This includes a focus on the systemic character of business models and the systems approaches that this entails. Another important aspect is to allocate more attention to innovations of business models. The business models that emerged with e-commerce and e-business as such were in themselves innovations. However, innovations of business models have received too little attention. Most of the business models analyzed and discussed in the business model literature have been rather static instead of dynamic. This is the reason why this Special Issue of Systems, entitled ‘Business Model—the Perspective of Systems Thinking and Innovation’, has been developed.

Listed by Unglue.it.

The clinical spectrum of systemic lupus erythematosus (SLE) is highly heterogeneous, ranging from mild disease, which can be limited to skin and joint involvement, to life-threatening conditions with renal impairment, severe cytopenias, central nervous system disease, and thromboembolic events. Apart from the host genetics, several environmental factors, such as sunlight, infections, drugs, and probably hormonal factors, can trigger the onset of symptoms related to SLE. Despite significant advances in our understanding of the pathophysiology and optimization of medical care, patients with SLE still have significant rates of premature mortality and many patients experience severe disease with increased risk of sustaining organ damage and having a reduced health-related quality of life. The development of effective drugs that can induce remission or low disease activity, the unanimous use of definitions of remission and low or high disease activity, flare, and response to therapy, the identification of non-invasive biomarkers of disease activity and long-term outcomes, and the implementation of SLE patients’ perspectives as an integral part of the clinical assessment constitute only a few of the many unmet needs in the field of SLE.

Listed by Unglue.it.

When the domestic government, the private sector, and people in various professional fields talk about long-term care issues, they all focus on creating a warm and home-like care institution. However, we actively emphasize the importance of community-based long-term care. For “aging in place”, the development of domestic non-institutional care is still in its infancy, and some long-term care needs must still be met through institutional care, and the facilitation of the extension or outreach of community-based care and respite service platforms for the development of community-based long-term care still rely on institutional care. The history of the development of long-term care in Taiwan is much shorter than that of Japan, Europe, the United States, and Canada. Despite years of hard work and rapid development, the long-term care resources needed to establish a complete system in terms of universalization, fairness, accessibility, and selectivity are not available. In the future, based on the soundness of institutional care, it hoped that outreach will move toward the goals of community care and aging in place. We hope the studies in this Special Issue will help further develop clinical medicine for healthcare and stainability.

Listed by Unglue.it.

Despite major medical advances in recent decades, colorectal cancer remains a major public health problem with significant unmet medical needs. This reprint presents new scientific and clinical data, and discusses the need to identify new theranostic biomarkers from tissue and fluid biopsies, to go further in terms of personalised medicine and thus overcome current limitations.

Listed by Unglue.it.

This open access edited collection brings together established and new perspectives on Cold War civil defence in Western Europe within a common analytical framework that also facilitates comparative and transnational dimensions. The current interest in creating disaster-resilient societies demands new histories of civil defence. Historical contextualization is essential in order to understand what is at stake in preparing, devising, and implementing forms of preparedness, protection, and security that are specifically targeted at societies and citizens. Applying the concept of sociotechnical imaginaries to civil defence history, the chapters of this volume cover a range of new themes, from technology and materiality to media, memory, and everyday experience. The book underlines the social embeddedness of civil defence by detailing how it both prompted new forms of social interaction and reflected norms and visions of the ‘good society’ in an age where nuclear technology seemed to hold the key to both doom and salvation.

Listed by Unglue.it.

The rapid aging of populations in developed countries since the 2000s has placed increasing attention on the issue of musculoskeletal disorders in elderly patients. Notably, spinal disorders not only restrict the social activities of elderly patients, but they also lead to economic loss for society. “Current Advances in Spinal Diseases of Elderly Patients” is a topical collection of articles about current perspectives on diagnosis and treatment of spinal disorders including current surgical strategies. This Special Issue covers a broad range of issues, ranging from managing refractory states such as severe osteoporosis, spinal deformity, ossification of the spinal ligaments, and multiple arthropathy to managing lifestyle-related spinal diseases during the COVID-19 pandemic in elderly populations. We hope that the readers of this Special Issue find the contents interesting.

Listed by Unglue.it.

After our successful first Special Issue about bladder cancer, we proceeded with the second issue. Again, many international scientists submitted their newest research results in that extremely interesting field and followed our call for submissions. It is not only the collection and combination of old and new markers that could develop new possibilities, but also the focus on different classifications and sub-classifications that will unveil new ways in diagnostic and therapeutic approaches. It seems that the two established diagnostic tools will still play an important role, but new markers and diagnostics tools will present more detailed and more differentiated possibilities in the treatment of urinary bladder cancer. This second Special Issue is full of scientific results that could provide new ways to help patients with instruments for early diagnostics and with predictive and prognostic markers on their way to finding new and personalized strategies for therapy. The editors thank all of the submitting authors for their efforts and time spent on each manuscript. We hope that this Special Issue will prove useful to research work in bladder cancer in the future. We hope that many talented researchers will use multiple forms of art to improve their professional successes and to ameliorate diagnostics and therapy in bladder cancer.

Listed by Unglue.it.

This book focuses on parrots, which are among the most fascinating, attractive, and threatened birds, combining and synthesizing recent research on the biology, ecology, and conservation of both native and non-native parrot populations across the world.

Listed by Unglue.it.

With the development of the aquatic feed industry, new feedstuff and feed additives have been developed, but their roles on the growth and immunity of different aquaculture animals remain to be examined. In addition to essential nutrients, feedstuffs and feed additives must contain some biologically active constituents to support fish growth and wellness. However, some also have adverse effects on growth performance through the introduction of undesirable materials. This Special Issue focuses on the application of feedstuffs and additives in aquaculture species’ growth and immunity, especially recently developed feedstuff and additives.

Listed by Unglue.it.

In an era when many of us depend on debt to survive but struggle with its consequences, Financing Prosperity by Dealing with Debt draws together current thinking on how to solve debt crises and promote prosperity. By profiling existing action by credit unions and community organisations, alongside bold proposals for the future, with contributions from artists, activists and academics, the book shows how we can rethink the validity and inevitability of many contemporary forms of debt through organising debt audits, promoting debt cancellation and expanding member-owned co-operatives. The authors set out legal and political methods for changing the rules of the system to provide debt relief and reshape economies for more inclusive and sustainable flourishing. The book also profiles community-based actions that are changing the role of debt in economic, social and political life – among them, participatory art projects, radical advice networks and ways of financing feminist green transition. While much of the research and activism documented here has taken place in London, the contributors show how different initiatives draw from and generate inspiration elsewhere, from debt audits across the global south, creative interventions around the UK and grassroots movements in North America. Financing Prosperity by Dealing with Debt moves beyond critique to present a wealth of concrete ways to tackle debt and forge the prosperous communities we want for the future.

Listed by Unglue.it.

The 22 papers that make up this Special Issue deal with pathogen and pest impact on forest health, from the diagnosis to the surveillance of causative agents, from the study of parasites’ biological, epidemiological, and ecological traits to their correct taxonomy and classification, and from disease and pest monitoring to sustainable control strategies.

Listed by Unglue.it.

Gastrointestinal cancers, such as esophageal and gastric cancers, pancreatic cancers, hepatobiliary cancers, colorectal cancers and gastrointestinal stromal tumors, are frequently diagnosed at an advanced stage and have a dismal prognosis. Even in patients with potentially curative cancer, nearly 50\% will develop recurrent disease despite aggressive treatments. A number of biomarkers currently guide treatment decisions for patients with gastrointestinal neoplasms. Major technological advances in genomics have made it possible to identify critical genetic alterations in cancer, furthering oncology along the path to “personalized cancer medicine”. Future research efforts will focus on the identification of new biomarkers, moving existing biomarkers into earlier lines of therapy and evaluating new combinations of existing biomarkers and therapies.The aim of this Special Issue is to provide an overview of exciting new research in the area of gastrointestinal tumors that may establish innovative personalized management and precision medicine modalities for individualized care.

Listed by Unglue.it.

Gastrointestinal (GI) malignancies represent a diverse spectrum of cancers with notable global incidence and prevalence. The comprehensive care of individuals affected by these malignancies is a multifaceted endeavor involving the collaboration of various medical disciplines. The nonspecific clinical manifestations of GI cancers often present a formidable diagnostic challenge to primary care providers, resulting in diagnostic delays. Subsequently, the treatment regimens, once initiated, are often demanding and prolonged, and profoundly impact the patients' overall quality of life. Given the intricate involvement of the digestive system, nutritional concerns are pervasive among these patients, influencing both their quality of life and survival. Despite these considerable challenges, the evolving landscape of treatment modalities has yielded improved outcomes, enabling a greater number of patients to achieve remission or extended survival. It is now imperative that we delve deeper into understanding the unique needs of this patient population and refine the care delivery pathways through enhanced diagnostic approaches, treatment strategies, and holistic support, and ultimately enhance the overall value of care provided to individuals afflicted by GI malignancies.

Listed by Unglue.it.