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Plant alkaloids are critical components of modern medicine and pharmaceuticals. These compounds are also becoming increasingly important for industrial uses as part of the green chemistry revolution. This Special Issue will focus on the molecular advances being made in understanding how such a large and diverse class of compounds are made by plants and how metabolic engineering advances are increasing the overall yield of crucial precursors.

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Dear colleagues, This Special Issue aims to publish new and innovative research that could demonstrate the therapeutic potential of natural health products, through relevant in vitro and/or in vivo biological activities, to prevent or alleviate degenerative diseases. The interaction of natural health products with human microbiota represents an essential aspect, because it could modulate the microbial pattern and alleviate more of a chronic disease’s effects in the case of type 2 diabetes, cardiovascular dysfunctions, neurodegenerative diseases, and inflammatory colon pathologies. Additionally, you are invited to send research based on the effect of different extracts or functional foods used in degenerative pathologies and interactions with human microbiota. We aim to identify new data on in vitro/in vivo research that could demonstrate the bioavailability of natural compounds and the relationship with antioxidant/antimicrobial capacity. Modulated microbiota aspects are expected to be published based on the interaction with natural compounds, natural sweeteners, or other molecules that influence the colon health status.

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Numerous studies have demonstrated that the plant microbiome is highly relevant for the growth and fitness of plants. Plants in ecosystems and agroecosystems can recruit a wide variety of microorganisms, including beneficial microbes which are being studied and applied as biostimulators to improve nutrition and tolerance of plants and as biocontrol of phytopathogens. In this context, this Book contains a selection of articles describing diverse ecological and biotechnological aspects of microbiomes in native and agronomic plants (e.g., pepper, potato, rice and lettuce) created by researchers from Italy, China, Korea, Egypt, Oman, Germany, the USA, and Chile.

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Fungi are important components of ecosystems. Their level of diversity is very high and only lower than that of insects. This book deals with fungal diversity in the Mediterranean, a large area recognized as a biodiversity hot spot. Micro and macrofungi contribute to characterizing many environments, both terrestrial and marine, in which they are associated with particular forest stands and also contribute to providing plant and soil nutrients. They also show potential applications in the medical and pharmaceutical fields, have a recognized nutritional and commercial value and still provide many insights to scholars in terms of description of new species and actions aimed at in situ and ex situ conservation.

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This Special Issue of Marine Drugs gathers recent investigations on the proteomes, metabolomes, transcriptomes, and the associated microbiomes of marine jellyfish and polyps, including bioactivity studies of their compounds and more generally, on their biotechnological potential, witnessing the increasingly recognized importance of Cnidaria as a largely untapped Blue Growth resource for new drug discovery. These researches evoke the outstanding ecological importance of cnidarians in marine ecosystems worldwide, calling for a global monitoring and conservation of marine biodiversity, so that the biotechnological exploitation of marine living resources will be carried out to conserve and sustainably use the natural capital of the oceans.

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The book entitled Medicinal Plants and Natural Product Research describes various aspects of ethnopharmacological uses of medicinal plants; extraction, isolation, and identification of bioactive compounds from medicinal plants; various aspects of biological activity such as antioxidant, antimicrobial, anticancer, immunomodulatory activity, etc., as well as characterization of plant secondary metabolites as active substances from medicinal plants.

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In the past few decades, awareness of the basic role that endophytic fungi play in shaping the fitness of both wild and crop plants has increased significantly. The number of papers on the subject is so large that it is becoming difficult to have a complete overview of the state-of-the-art with reference to specific crops. In the absence of readily available documents providing circumstantial information on the endophytic assemblage of plants, the isolation of a certain fungal species may appear to be occasional or trivial; hence, many important findings are at risk of going unnoticed. This Special Issue aims to present a collection of papers dealing with the occurrence and functions of endophytic fungi in crop species. It may represent a useful tool for stakeholders in this particular research field, with a view to stimulating a more thorough consideration of the opportunities deriving from their discoveries.

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This book is a printed edition of the Special Issue Promising Detoxification Strategies to Mitigate Mycotoxins in Food and Feed that was published in Toxins

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