Introducing “A Feasible Approach for Natural Products to Treatment of Diseases”–an exploration of the therapeutic potential locked within nature’s abundant offerings. This comprehensive reprint delves into the fascinating realm of natural products, uncovering their inherent properties, mechanisms of action, and potential roles in effective disease management. Through extensive scientific research and reviews, the authors shed light on the immense potential of natural products as a viable approach to enhancing health and combating diseases. This reprint presents a diverse and multidimensional exploration, bridging the gap between traditional wisdom and contemporary scientific understanding and offering new avenues for healthcare professionals, researchers, and enthusiasts to harness the power of nature’s remarkable resources. As a catalyst for unlocking the healing potential of natural products, this reprint inspires further investigation and innovation, and drives us towards a future where their integration into mainstream healthcare becomes indispensable. Discover the possibilities and embark on a health and well-being journey with “A Feasible Approach for Natural Products to Treatment of Diseases”.

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In the last few decades, various composite gels have been developed. In recent years, further advances have been made in the development of novel composite gels with potential applications in various fields. This reprint offers the latest findings of composite gels by experts throughout the world.

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Due to increasing concern about the use of pesticides and its potential side effects, this book considers the development and application of alternative, environmental-friendly, plant protection methods for the control of weeds, disease, and pests (predators, parasitoids, competitors, plant-plant interactions, microelements, biopesticides). Some of the main advantages of the measures presented in papers are the absence of toxicity to humans and vertebrates, beneficial organisms, and the environment, as well as the absence of pest resistance. In order to provide sustainable and eco-friendly food production, those are important subjects, both in conventional, organic and integrated agricultural farming. Through reviews and original research articles, this reprint covers all aspects of alternative measures in plant protection.

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Carotenoids are a group of natural pigments, consisting of more than 750 compounds. They are mostly yellow, orange, or red in color, due to the system of conjugated double bonds. This structural element is also responsible for the good antioxidant properties of many carotenoids. Carotenoids have shown numerous biological activities (not only as provitamin A), e.g., preventive properties of fruits and vegetables. As lipophilic compounds, their uptake and storage in the body are dependent on various conditions. In vitro and in vivo data showed stimulating and inhibitory effects of matrix compounds on bioaccessibility and bioavailability of carotenoids.

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Biomass corresponds to organic matter of animal, vegetable, microbial, or algal origin. Biomass use as feedstock for biomaterial, chemicals, platform molecules, biofuel or bioenergy are the most reliable alternatives to limit fossil fuel consumption and to reduce greenhouse gas emissions. Resource recovery from different kinds of waste, such as sludge, food waste, municipal solid waste, and animal waste (manure and slaughterhouse waste), is particularly interesting from an environmental point of view, as it also reduces environmental pollution. In addition, lignocellulosic biomass and algae, which do not compete for food production, represent an important source of renewable resources (i.e., energy and other value-added products). However, a pretreatment step is generally required before biomass (bio)-conversion into valuable products in order to increase the process yield and/or productivity.Pretreatments are applied upstream of various conversion processes of biomass into biofuel or biomaterial with valuable end products such as bioethanol, biohydrogen, biomethane, biomolecules or biomaterials. Pretreatments cover a wide range of processes that include mechanical, thermal, chemical and biological techniques. This step is recognized as crucial and cost intensive for the development of biorefineries. Thus, more research is necessary to identify the most effective and economical pretreatment options for different biomass sources.

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The visual system consists of hierarchically organized distinct anatomical areas functionally specialized for processing different aspects of a visual object (Felleman & Van Essen, 1991). These visual areas are interconnected through ascending feedforward projections, descending feedback projections, and projections from neural structures at the same hierarchical level (Lamme et al., 1998). Accumulating evidence from anatomical, functional and theoretical studies suggests that these three projections play fundamentally different roles in perception. However, their distinct functional roles in visual processing are still subject to debate (Lamme & Roelfsema, 2000). The focus of this Research Topic is the roles of feedforward and feedback projections in vision. Even though the notions of feedforward, feedback, and reentrant processing are widely accepted, it has been found difficult to distinguish their individual roles on the basis of a single criterion. We welcome empirical contributions, theoretical contributions and reviews that fit into any one (or a combination) of the following domains: 1) their functional roles for perception of specific features of a visual object 2) their contributions to the distinct modes of visual processing (e.g., pre-attentive vs. attentive, conscious vs. unconscious) 3) recent techniques/methodologies to identify distinct functional roles of feedforward and feedback projections and corresponding neural signatures. We believe that the current Research Topic will not only provide recent information about feedforward/feedback processes in vision but also contribute to the understanding fundamental principles of cortical processing in general.

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The use of formulae has become widespread in recent years across most developed countries. In the UK, a conservative estimate is that annually £150 billion of public service expenditure is distributed using formulae, in services such as health care, local government, social security and higher education. This book offers a comprehensive introduction to the theory and practice underlying the use of such formulae as a basis for funding public services. The philosophy, design and economic consequences of funding formulae have become key policy issues worldwide. However, till now, there has been no text which brings together the economic, statistical and political issues underlying formula funding. This key book fills that gap. Written by a leading international expert on the design of funding formulae, this important book includes empirical evidence from a range of countries and will be a valuable resource for all those involved in this field.

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The use of formulae has become widespread in recent years across most developed countries. In the UK, a conservative estimate is that annually £150 billion of public service expenditure is distributed using formulae, in services such as health care, local government, social security and higher education. This book offers a comprehensive introduction to the theory and practice underlying the use of such formulae as a basis for funding public services. The philosophy, design and economic consequences of funding formulae have become key policy issues worldwide. However, till now, there has been no text which brings together the economic, statistical and political issues underlying formula funding. This key book fills that gap. Written by a leading international expert on the design of funding formulae, this important book includes empirical evidence from a range of countries and will be a valuable resource for all those involved in this field.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

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The use of new information and communication technologies both inside the courts and in private online dispute resolution services is quickly changing everyday conflict management. However, the implications of the increasingly disruptive role of technology in dispute resolution remain largely undiscussed. In this book, assistant professor of law and digitalisation Riikka Koulu examines the multifaceted phenomenon of dispute resolution technology, focusing specifically on private enforcement, which modern technology enables on an unforeseen scale. The increase in private enforcement confounds legal structures and challenges the nation-state’s monopoly on violence. And, in this respect, the author argues that the technology-driven privatisation of enforcement – from direct enforcement of e-commerce platforms to self-executing smart contracts in the blockchain – brings the ethics of law’s coercive nature out into the open. This development constitutes a new, and dangerous, grey area of conflict management, which calls for transparency and public debate on the ethical implications of dispute resolution technology.

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The publication explores migrant integration in the Czech Republic, Slovakia, Belgium (Flanders) and Germany (Bavaria) with the aim to understand the unique situational context of each country and to find opportunities for mutual learning and sharing of best practices. First, the realities in the four examined countries are introduced, focusing on strategic materials, key actors and mutual expectations from migrants and the receiving societies. The Czech Republic and Slovakia are inspected in greater detail as less information is generally available on the situation in the two countries. After exploring the countries’ approaches to migrants (especially at the local level), the book presents unique inspirational practices that can be a source of inspiration to others. Finally, the publication examines the challenges faced by the four countries in terms of local integration of migrants, and gives a number of practical recommendations. The publication follows developments up to the end of 2021.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

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Multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) Gram-negative bacteria constitute a huge public health problem. Among them, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii are the main bacteria contributing to increased rates of antimicrobial resistance. Infections caused by these bacteria can have a negative impact on the financial costs and outcomes of patient hospitalization. The increased consumption of antimicrobials and the poor implementation of infection control measures in the hospital setting are the two main causative factors for their emergence. Deep knowledge of the virulent factors that these bacteria produce could provide useful information regarding their spread. The main problem concerning infections caused by these bacteria is that treatment options are extremely limited, as there has been a poor launch of novel antimicrobials over the last few years. The molecular epidemiology of infections caused by Gram-negative bacteria is significant as it can determine which of these few new antimicrobial agents could be effective for their treatment. This Special Issue collects manuscript submissions that expand our knowledge of antimicrobial resistance in Gram-negative bacteria.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

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Recently, a revolution in nanotechnology has pervaded all fields related to animal science. This book collection focuses on the potential applications of nanotechnology in the field of animal science, particularly livestock production and medication. The studies/reviews published in this book show the preparation protocols and physiochemical and biological properties of the innovated nanoparticles, designated for different purposes. This is in line with the potential hazards of these materials. The book collection shows that nanoparticles and nanoparticle-based systems can be developed to serve different purposes in the field of animal production and veterinary, such as the management of reproduction and assisted reproductive techniques, rapid and robust disease diagnosis and treatment, drug delivery, and animal nutrition.

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Neurodegenerative disorders are characterized by the progressive loss of specific populations of neurons with consequent deterioration of brain's function and dramatic impact on human behavior. At present, there are no effective cures for neurodegenerative diseases. Because unambiguous diagnosis is possible only after manifestation of symptoms, when a large proportion of neurons has been already lost, therapies are necessarily confined to alleviation of symptoms. Development of cures halting the disease course is hampered by our rudimentary understanding of the etiopathology. Most neurodegenerative disorders are sporadic and age-related and - even for those of known genetic origin - the mechanisms influencing disease onset and progression have not been fully characterized. The different diseases, however, share important similarities in the mechanisms responsible for neuronal loss, which is caused by a combination of endogenous and exogenous challenges. Trophic deprivation, oxidative stress, accumulation of abnormal protein aggregates, and bioenergetics defects have been described in most, if not all, neurodegenerative disease. To counterbalance these noxious stimuli cells deploy, at least during the initial pathogenic states, intrinsic neuroprotective responses. These are general compensatory mechanisms, common to several neurodegenerative conditions, which reprogram cellular physiology to overcome stress. Adaptation includes strategies to optimize energetic resources, for instance reduction of rRNA synthesis to repress translation, suppression of transcription, and bioenergetics and metabolic redesign. Additional mechanisms include potentiation of antioxidant capacity, induction of endoplasmic reticulum (ER) stress, and activation of protein quality control systems and autophagy. Ineffective execution of these compensatory strategies severely threatens cellular homeostasis and favors onset of pathology. Therefore, a better understanding of these "buffering" mechanisms and of their interconnections may help to devise more effective therapeutic tools to prolong neuronal survival and activity, independently of the original genetic mutations and stress insults. This Research Topic focuses on the initial compensatory responses protecting against failure of those mechanisms that sustain neuronal survival and activity. The collection intends to summarize the state-of-the-art in this field and to propose novel research contributes, with the ultimate goal of inspiring innovative studies aimed to contrast progression of neurodegenerative diseases.

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Zinc oxide (ZnO) nanostructure, one of most famous nanomaterials in past decades, provides extensive and adaptive applications to wide communities include material, physics, daily-use chemical industry and medical societies. Controlled synthesis, advancing characterization tools, and endless healthcare from materials, drive rapid evolution of understanding and engineering on ZnO nanomaterials. Here, in this reprint, novel research articles and mini reviews are included with the focus on the novel synthesis, applications on the air and liquid purifications by using the photocatalytic merits of ZnO. Additionally, antibacterial performance from the ZnO nanostructures were demonstrated by these original contributions, which directs the new possibility from ZnO towards medical usage.

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Concrete is one of the most widely used construction material in the word today. The research in concrete follows the environment impact, economy, population and advanced technology. This special issue presents the recent numerical study for research in concrete. The research topic includes the finite element analysis, digital concrete, reinforcement technique without rebars and 3D printing.

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There is unequivocal experimental, epidemiological, and clinical evidence demonstrating a correlation between diet and increased risk of cardiovascular disease (CVD). While nutritionally-poor diets can have a significant negative impact on cardiovascular health, dietary interventions with specific nutrients and/or functional foods are considered cost-effective and efficient components of prevention strategies. It has been estimated that nutritional factors may be responsible for approximately 40% of all CVD. Indeed, in one of the seminal studies conducted on modifiable risk factors and heart health (the INTERHEART study), >90% of all myocardial infarctions were attributed to preventable environmental factors with nutrition identified as one of the important determinants of CVD. There is an increasing public interest in and scientific investigation into establishing dietary approaches that can be undertaken for the prevention and treatment of CVD. This Special Issue provides an insight into the influential role of nutrition and dietary habits on cardiovascular health and disease, as well as their mechanisms of therapeutic and preventive action.

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Since its invention, concrete has become the most widely used construction material. Growing concerns over the greenhouse emissions profile of the Portland cement and concrete industry have led to a very high level of recent interest in the development of low-carbon construction materials. The requirements of raw materials for cement and concrete, such as natural minerals, stones, and river sand, have been increasing, especially in developing countries where massive amounts of infrastructure are being built. This trend promotes the requirements of sustainable cementitious materials with low carbon emissions for civil and transportation engineering. The development of low-carbon construction materials has been recognized as a means of reducing the carbon footprint of the Portland cement and concrete industry in response to growing global concerns over natural-material shortages and CO2 emissions from the construction sector. The concrete and cement industry has been under pressure to shift towards sustainability by developing alternative low-carbon cement and concrete materials. However, many fundamental mechanisms in this field require further elucidation. In addition, industrial applications are still scarce due to the gap existing between the fundamental research and industrial use in this area.

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Nature has always been, and still is, a source of food and ingredients that are beneficial to human health. Nowadays, plant extracts are increasingly becoming important additives in the food industry due to their antimicrobial and antioxidant activities that delay the development of off-flavors and improve the shelf life and color stability of food products. Due to their natural origin, they are excellent candidates to replace synthetic compounds, which are generally considered to have toxicological and carcinogenic effects. The efficient extraction of these compounds from their natural sources and the determination of their activity in commercialized products have been great challenges for researchers and food chain contributors to develop products with positive effects on human health. The objective of this Special Issue is to highlight the existing evidence regarding the various potential benefits of the consumption of plant extracts and plant-extract-based products, with emphasis on in vivo works and epidemiological studies, the application of plant extracts to improving shelf life, the nutritional and health-related properties of foods, and the extraction techniques that can be used to obtain bioactive compounds from plant extracts.

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Science has tremendously advanced our understanding of the pathophysiology of chronic pain. Breakthrough findings include functional and structural brain changes, neuro-inflammation, sensory changes, immune alterations, psychological problems, neurocognitive disorders, stress intolerance, sleep impairments, and (epi)genetic changes found in patients with chronic pain. This Journal of Clinical Medicine Boutique Special Issue focuses on the broad field of the biology of chronic pain in humans. It includes invited state-of-the-art papers addressing key biological processes in patients with chronic pain and original research reports. The state-of-the-art papers were written by leading experts and key opinion leaders in the field. This Special Issue contributes to an exciting area of tremendous advancements and breakthrough research.

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

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Transcriptional regulation is a critical biological process involved in the response of a cell, a tissue or an organism to a variety of intra- and extra-cellular signals. Besides, it controls the establishment and maintenance of cell identity throughout developmental and differentiation programs. This highly complex and dynamic process is orchestrated by a huge number of molecules and protein networks and occurs through multiple temporal and functional steps. Of note, many human disorders are characterized by misregulation of global transcription since most of the signaling pathways ultimately target components of transcription machinery. This book includes a selection of papers that illustrate recent advances in our understanding of transcriptional regulation and focuses on many important topics, from cis-regulatory elements to transcription factors, chromatin regulators and non-coding RNAs, other than several transcriptome studies and computational analyses.

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Find out an innovative exploration of online violence through this book, which is the result of an unprecedented collaboration between Bordeaux Montaigne University and the French National Police Service, within the “CyberNeTic” research project. It explores underlying cyberbullying practices and its violent mechanisms as it gets to the heart of communication and information sciences as well as cybercriminology. It can also provide a typology of over forty modes of operation. This approach offers a nuanced, multidisciplinary understanding of this modern scourge. Both academic and practical, this book focuses on a specific scientific definition of identified cyberbullying practices. Along with these online crime explorations, harrowing testimonial integrations and concrete examples presentations, it is in fact relying on the in-depth legal framework and providing scientific references that are essential for a better full apprehending of the issue. This book is a keen resource for all professionals confronted to digital violence or committed to create a safer online space.

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Complex systems are to be seen as typically having multiple levels of organization. For instance, in the behavioural and cognitive sciences, there has been a long lasting trend, promoted by the seminal work of David Marr, putting focus on three distinct levels of analysis: the computational level, accounting for the What and Why issues, the algorithmic and the implementational levels specifying the How problem. However, the tremendous developments in neuroscience knowledge about processes at different scales of organization together with the complexity of today cognitive theories suggest that there will hardly be only three levels of explanation. Instead, there will be many different degrees of commitments corresponding to the different granularities - from high-level (behavioural) models to low-level (neural and molecular) models of the cognitive research program. For instance, Bayesian approaches, that are usually advocated for formalizing Marr's computational level and rational behaviour, have even been adopted to model synaptic plasticity and axon guidance by molecular gradients. As a result, we can consider the behavioural scientist as dealing with models at a multiplicity of levels. The purpose of this Research Topic in Frontiers in Theoretical and Philosophical Psychology is to promote an approach to the role of the levels and explanation and models which is of interest for cognitive scientists, neuroscientists, psychologists, behavioural scientists, and philosophers of science.

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