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Electrical Brain Stimulation: Mechanisms and Modulation of Neuronal Activity
Zhouyan Feng
2026
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This open access book explores the mechanisms and modulation of invasive neural electrical stimulation in the brain. Drawing from the author's extensive research experience, it offers in-depth yet accessible content, enriched with vivid illustrations and practical applications. Notably, the book provides detailed techniques for animal experiments and methods for recording and processing neural electrical signals with a depth rare in similar works. The book is divided into two parts. Part I introduces fundamental electrophysiological theories and experimental methods. It covers the basic electrical properties of neuronal membranes, the famous Hodgkin-Huxley mathematical model, hippocampal neural networks and electrically evoked potentials, in-vivo rat experimental methods and equipment, and techniques for recording and processing neural electrical signals. Part II focuses on neural modulation through various electrical stimulations. It examines how various patterns of high-frequency pulse stimulations affect individual neurons, neuronal populations, and neural networks. In addition to exploring neuronal responses to electrical stimulation under normal physiological conditions, this part also investigates the inhibitory effects of high-frequency stimulation on epileptiform activity. This comprehensive book can serve as a valuable reference for researchers, teachers, students, and enthusiasts in the fields of neurophysiology, neural signal analysis, neural engineering, neuromodulation, brain stimulation, and brain-computer interfaces. It also provides excellent supplementary material for undergraduate and graduate courses in biomedical signal processing, neural engineering, and neuroscience.
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Keywords
- Axonal block
- Brain stimulation
- brain-computer interfaces
- Deep Brain Stimulation
- Desynchronization Effect of High-Frequency Stimulation
- Evoked potential
- high-frequency stimulation
- Hippocampus
- In-vivo rat experiment
- interneuron
- local field potential
- neural engineering
- Neural modulation
- Neural signal processing
- Non-linear Neuronal Firing
- open access
- Population spike
- pyramidal neuron
- thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQW Biomedical engineering
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
- Unit spike
Links
DOI: 10.1007/978-981-95-4145-4Editions