Explore
Comparative studies between HTLV-1 and HTLV-2 function and pathobiology
Umberto Bertazzoni and Francoise Bex
2015
0 Ungluers have
Faved this Work
Login to Fave
Human T-cell leukemia viruses type 1 and 2 (HTLV-1 and HTLV-2) share a common genetic organization, expression strategy and ability to infect and immortalize T-cells in vitro; however, HTLV-1 and HTLV-2 are strikingly different in terms of clinical impact. HTLV-1 is recognized as the aetiological agent of adult T-cell leukemia/lymphoma (ATLL), and HTLV-associated myeolopathy/tropical spastic paraparesis (HAM/TSP), in contrast, HTLV-2 does not cause hematologic disorders and is only sporadically associated with cases of subacute myelopathy. HTLV-1 and HTLV-2 also exhibit distinct cellular tropisms in vivo: HTLV-1 is mainly found in CD4+T lymphocytes, whereas CD8+T-cells are the preferred target for HTLV-2. The articles contributed in this Research Topic are covering all the different aspects that characterize HTLV-1 and HTLV-2, by highlighting differences in their biology that might provide clues to their distinct pathogenic properties.
This book is included in DOAB.
Why read this book? Have your say.
You must be logged in to comment.
Rights Information
Are you the author or publisher of this work? If so, you can claim it as yours by registering as an Unglue.it rights holder.Downloads
This work has been downloaded 107 times via unglue.it ebook links.
- 41 - mobi (CC BY) at Unglue.it.
- 31 - epub (CC BY) at Unglue.it.
- 35 - pdf (CC BY) at Unglue.it.
Keywords
- Co-infection
- Expression
- HTLV-1
- HTLV-2
- Proteins
Links
DOI: 10.3389/978-2-88919-498-8Editions