Explore
Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation
Alberto Granato and Andrea De Giorgio
2015
0 Ungluers have
Faved this Work
Login to Fave
Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
This book is included in DOAB.
Why read this book? Have your say.
You must be logged in to comment.
Rights Information
Are you the author or publisher of this work? If so, you can claim it as yours by registering as an Unglue.it rights holder.Downloads
This work has been downloaded 99 times via unglue.it ebook links.
- 5 - epub (CC BY) at Unglue.it.
- 5 - epub (CC BY) at Unglue.it.
- 32 - mobi (CC BY) at Unglue.it.
- 20 - epub (CC BY) at Unglue.it.
- 28 - pdf (CC BY) at Unglue.it.
Keywords
- Amygdala
- Apoptosis
- Cerebral Cortex
- Development
- epigenetics
- Fetal Alcohol Spectrum Disorders
- glial cells
- Intellectual Disability
- medicine
Links
DOI: 10.3389/978-2-88919-472-8Editions