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Harnessing oncolytic virus-mediated immunity
Philippe Fournier and Volker Schirrmacher
2015
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Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.
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Keywords
- anti-tumor activity
- anti-viral response
- immunotherapeutic approaches
- immunovirotherapy
- medicine
- Oncolytic Virotherapy
- oncolytic virus
- tumor-associated antigen
Links
DOI: 10.3389/978-2-88919-450-6Editions