Explore
Neuroanatomy and transgenic technologies
0 Ungluers have
Faved this Work
Login to Fave
Neuroanatomists increasingly rely on techniques enabling them to manipulate genes in defined brain cell populations. In particular, engineered transgenes, which encode a variety of fluorescent reporter proteins can be inserted into the genome or delivered into desired brain regions using viral vectors, thereby allowing the labeling of molecularly-defined populations of neurons and/or glial cells. Transgenic technology can also be used to selectively delete genes in targeted neuronal populations or bi-directionally modulate their electrical excitability using optogenetic or chemogenetic techniques. One of the primary advantages of using transgenic reagents is to simplify the identification and tracing of targeted population of brain cells, which can be laborious using traditional techniques in neuroanatomy. In this research topic, we assembled up-to-date reviews and original articles that demonstrate the versatility and power of transgenic tools in advancing our knowledge of the nervous system, with a special emphasis on the application of transgenic technology to neuroanatomical questions.
This book is included in DOAB.
Why read this book? Have your say.
You must be logged in to comment.
Rights Information
Are you the author or publisher of this work? If so, you can claim it as yours by registering as an Unglue.it rights holder.Downloads
This work has been downloaded 136 times via unglue.it ebook links.
- 14 - epub (CC BY) at Unglue.it.
- 17 - epub (CC BY) at Unglue.it.
- 41 - mobi (CC BY) at Unglue.it.
- 25 - epub (CC BY) at Unglue.it.
- 33 - pdf (CC BY) at Unglue.it.
Keywords
- adeno-associated virus
- Biology, Life Sciences
- Fluorescent reporters
- gene delivery
- Life sciences: general issues
- Mathematics & science
- Morphology
- mouse models
- neuronal circuits
- Neurosciences
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
- tracing
- transgenesis
Links
DOI: 10.3389/978-2-88919-513-8Editions