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The role of arginase in endothelial dysfunction
Rudolf Lucas
2015
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In recent years, an increasing number of manuscripts have been published addressing the deleterious role of arginase in endothelial dysfunction. ROS have been shown to play a crucial role in arginase activation, which in turn leads to eNOS dysfunction.
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Keywords
- arginase inhibitors
- eNOS
- impaired vasorelaxation
- L-citrulline
- microvascular permeability
- Reactive Oxygen Species
- vessel wall remodeling