Explore
The Role of Glia in Plasticity and Behavior
Vladimir Parpura and Tycho Hoogland
2016
0 Ungluers have
Faved this Work
Login to Fave
Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
This book is included in DOAB.
Why read this book? Have your say.
You must be logged in to comment.
Rights Information
Are you the author or publisher of this work? If so, you can claim it as yours by registering as an Unglue.it rights holder.Downloads
This work has been downloaded 130 times via unglue.it ebook links.
- 6 - epub (CC BY) at Unglue.it.
- 11 - epub (CC BY) at Unglue.it.
- 43 - mobi (CC BY) at Unglue.it.
- 30 - epub (CC BY) at Unglue.it.
- 28 - pdf (CC BY) at Unglue.it.
Keywords
- Astrocytes
- Behavior
- Biology, Life Sciences
- C. elegans
- Cerebellum
- Cortex
- DREADD
- glia
- Gq
- Hippocampus
- Life sciences: general issues
- Mathematics & science
- Neurosciences
- Plasticity
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
Links
DOI: 10.3389/978-2-88919-690-6Editions