Explore
Cellular Entry of Binary and Pore-Forming Bacterial Toxins
0 Ungluers have
Faved this Work
Login to Fave
Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein–lipid and protein–protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification.This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues.
This book is included in DOAB.
Why read this book? Have your say.
You must be logged in to comment.
Rights Information
Are you the author or publisher of this work? If so, you can claim it as yours by registering as an Unglue.it rights holder.Downloads
This work has been downloaded 47 times via unglue.it ebook links.
- 13 - pdf (CC BY-NC-ND) at Unglue.it.
Keywords
- bacterial protein toxins
- cellular uptake
- conformational switching
- membrane permeabilization and translocation
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
- toxin-based targeted delivery of therapeutic agents
- toxin-membrane interactions
Links
DOI: 10.3390/books978-3-03842-703-2Editions