Explore
Reelin-Related Neurological Disorders and Animal Models
0 Ungluers have
Faved this Work
Login to Fave
The Reeler mutation was so named because of the alterations in gait that characterize homozygous mice. Several decades after the description of the Reeler phenotype, the mutated protein was discovered and named Reelin (Reln). Reln controls a number of fundamental steps in embryonic and postnatal brain development. A prominent embryonic function is the control of radial neuronal migration. As a consequence, homozygous Reeler mutants show disrupted cell layering in cortical brain structures. Reln also promotes postnatal neuronal maturation. Heterozygous mutants exhibit defects in dendrite extension and synapse formation, correlating with behavioral and cognitive deficits that are detectable at adult ages. The Reln-encoding gene is highly conserved between mice and humans. In humans, homozygous RELN mutations cause lissencephaly with cerebellar hypoplasia, a severe neuronal migration disorder that is reminiscent of the Reeler phenotype. In addition, RELN deficiency or dysfunction is also correlated with psychiatric and cognitive disorders, such as schizophrenia, bipolar disorder and autism, as well as some forms of epilepsy and Alzheimer's disease. Despite the wealth of anatomical studies of the Reeler mouse brain, and the molecular dissection of Reln signaling mechanisms, the consequences of Reln deficiency on the development and function of the human brain are not yet completely understood. This Research Topic include reviews that summarize our current knowledge of the molecular aspects of Reln function, original articles that advance our understanding of its expression and function in different brain regions, and reviews that critically assess the potential role of Reln in human psychiatric and cognitive disorders.
This book is included in DOAB.
Why read this book? Have your say.
You must be logged in to comment.
Rights Information
Are you the author or publisher of this work? If so, you can claim it as yours by registering as an Unglue.it rights holder.Downloads
This work has been downloaded 149 times via unglue.it ebook links.
- 12 - epub (CC BY) at Unglue.it.
- 5 - pdf (CC BY) at Unglue.it.
- 8 - epub (CC BY) at Unglue.it.
- 54 - mobi (CC BY) at Unglue.it.
- 36 - epub (CC BY) at Unglue.it.
Keywords
- Autism
- automatic detection
- biomarker
- Depression
- Electroencephalography (EEG)
- intracellular pathways
- IQ
- Memory
- Neural oscillations
- Neuronal Death
- neuronal migration
- Neurons
- open access
- Reeler
- Schizophrenia
- sigma waves
- Sleep
- Sleep Spindles
- Synapses
- thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
Links
DOI: 10.3389/978-2-88945-111-1Editions