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Advances in Mechanisms of Renal Fibrosis
Hui Y. Lan and David J. Nikolic-Paterson
2018
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Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.
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Keywords
- BMP7
- fibroblast
- HDAC
- HIPK2
- JNK
- medicine
- miRNA
- non-classical RAS
- Physiology
- Pre-clinical medicine: basic sciences
- SMAD
- TGF-beta
- thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
Links
DOI: 10.3389/978-2-88945-499-0Editions