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Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.
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Keywords
- Aedes aegypti
- African-lineage
- anti-viral immunity
- antiviral
- antiviral compounds
- antiviral responses
- antivirals
- Apoptosis
- arbovirus
- Asian lineage
- Asian-lineage
- assay standardization
- astrocytomas
- Bacterial artificial chromosome
- Bayesian analyses
- blood-retinal barrier
- boolean logic-processing nucleic acid probes
- cell surface receptors
- chimeric viruses
- clinical trials
- congenital Zika syndrome
- cross-reactions
- cryptic promoter silencing
- cytopathic effects
- dengue virus
- dengue viruses
- detoxification and immune system responses
- Diagnosis
- dsRNA
- eIF4A
- ELISA
- emerging arbovirus
- EQA
- external quality assessment
- Eye
- fetal infection
- Flavivirus
- flaviviruses
- FSS13025
- Full-length cDNA infectious clones
- full-length molecular clone
- Gene expression
- Genetic variability
- heme-oxygenase 1
- hepatocytes
- host genetic variation
- host-directed antivirals
- human brain glial cells
- IgA
- IgG avidity tests
- Immune response
- indirect immunofluorescence
- Infection
- infectious cDNA
- infectious clone
- infectious RNA
- innate response
- insecticide resistance
- isothermal nucleic acid amplification
- laboratory preparedness
- Microcephaly
- microglia cells
- MicroRNAs
- microsphere immunoassay
- molecular diagnostics
- monoclonal antibodies
- mosquito
- mosquito surveillance
- mosquito-borne flavivirus
- MR766
- multiplex nucleic acid detection
- mutagenesis
- Natural history
- neural cells
- neural progenitor cells
- neuroinflammation
- Neurons
- neuropathogenesis
- NHP
- Non-human primates
- NS1 protein
- NS2A protein
- NS5
- nucleic acid computation
- nucleic acid strand exchange
- ocular
- optimised
- outbreak control
- placenta cells
- plaque reduction neutralization test
- plasmid toxicity
- point-of-care diagnostics
- Polymerase chain reaction
- Pregnancy
- prM-E proteins
- Prostate
- QCMD
- replication
- replicon
- reporter virus
- research models and tools
- Reverse genetics
- rhesus macaques
- RNA-Seq
- secondary infections
- Serology
- sexual transmission
- silvestrol
- siRNA
- subgenomic replicon
- testes
- testicular cells
- testis
- Tet-inducible
- Therapeutics
- Therapy
- TLR7/8
- type I IFN antagonist
- Vaccines
- validated
- viral counteraction
- viral evolution
- viral fitness
- viral genetic variation
- Viral pathogenesis
- viral pathogenicity
- viral permissiveness
- viral persistence
- viral replication
- viral survival
- virus attachment
- virus like particles
- Zika
- Zika virus
- Zika virus (ZIKV)
- Ziks virus
- ZIKV
- ZIKV-associated neurologic disorders
- ZIKV–host interactions
Links
DOI: 10.3390/books978-3-03897-765-0Editions