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Drug Metabolism, Pharmacokinetics and Bioanalysis
Hye Suk Lee and Kwang-Hyeon Liu
2019
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Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
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Keywords
- 129-Glatm1Kul/J
- aceclofenac
- acetyl tributyl citrate
- adalimumab
- aglycone
- alcohol addiction
- anthraquinone
- AUDIT score
- B6
- bioanalysis
- bioavailability
- biopharmaceuticals
- brain distribution
- caffeic acid
- caffeic acid O-glucuronides
- chlorogenic acid
- cryptochlorogenic acid
- CYP
- Cytochrome P450
- DA-9805
- diabetes
- diclofenac
- drug interaction
- drying technology
- efficacy
- esomeprazole
- ethyl glucuronide
- Eurycoma longifolia
- eurycomanone
- Fabry disease
- gastric ulcer
- GB3
- glucuronidation
- glycoside
- Hair
- HPLC-MS/MS
- human liver microsomes
- immunoprecipitation
- imperatorin
- Korean red ginseng extract
- LC-HR/MS
- LC-MS/MS
- LC-QTOF-MS/MS
- liquid chromatography-quadrupole TOF MS
- liquid chromatography-tandem mass spectrometry
- loxoprofen
- mematine
- metabolic stability
- metformin
- N-acetylprocainamide
- neochlorogenic acid
- organic anion transporting polypeptide
- Osthenol
- paeonol
- pharmaceutical excipient
- pharmacokinetic
- pharmacokinetics
- Plasma
- procainamide
- protein precipitation
- protein stability
- rat
- saikosaponin a
- Stauntonia hexaphylla leaf extract
- UGT
- ultra-high-pressure liquid chromatography
- YRA-1909
Links
DOI: 10.3390/books978-3-03897-917-3Editions
