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Multiscale Modeling of Cardiac Electrophysiology: Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment
Mathias Wilhelms
2013
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Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.
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Keywords
- acute cardiac ischemia
- Atrial Fibrillation
- Cardiac modeling
- parameter adaptation
- pharmacological therapy
Links
DOI: 10.5445/KSP/1000035360Editions