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Nucleic Acid Architectures for Therapeutics, Diagnostics, Devices and Materials
Kirill A. Afonin
2019
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Nucleic acids (RNA and DNA) and their chemical analogs have been utilized as building materials due to their biocompatibility and programmability. RNA, which naturally possesses a wide range of different functions, is now being widely investigated for its role as a responsive biomaterial which dynamically reacts to changes in the surrounding environment. It is now evident that artificially designed self-assembling RNAs, that can form programmable nanoparticles and supra-assemblies, will play an increasingly important part in a diverse range of applications, such as macromolecular therapies, drug delivery systems, biosensing, tissue engineering, programmable scaffolds for material organization, logic gates, and soft actuators, to name but a few. The current exciting Special Issue comprises research highlights, short communications, research articles, and reviews that all bring together the leading scientists who are exploring a wide range of the fundamental properties of RNA and DNA nanoassemblies suitable for biomedical applications.
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Keywords
- aggregation
- Aptamers
- biological media
- Biosensors
- conditional activation
- conditionally activated
- contrast variation
- cotranscriptional folding
- cytosine rich sequences
- DNA nanotechnology
- dynamic
- fluorescence
- fluorogenic RNA
- functional RNA
- ganciclovir
- gene delivery
- Gene Therapy
- glioblastoma multiforme
- i-motif DNA
- immunostimulation
- light-up aptamer
- live-cell imaging
- logic gates
- n/a
- nanopores
- NANPs
- non-viral gene delivery
- non-viral vector
- nucleic acid computing
- nucleic acid nanoparticle
- nucleic acid nanoparticles
- nucleic acid therapeutic
- riboswitch
- ribozyme
- RNA
- RNA aptamers
- RNA interference
- RNA logic
- RNA nanoparticle
- RNA nanotechnology
- RNA self-assembly
- serum
- silver nanoclusters
- siRNA
- small-angle neutron scattering
- small-angle X-ray scattering
- spinal cord tumor
- Stability
- Structural characterization
- suicide gene therapy
- viral vector
Links
DOI: 10.3390/books978-3-03921-260-6Editions
