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Recent Advances in Biocatalysis and Metabolic Engineering for Biomanufacturing
Eun Yeol Lee
2019
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The use of biocatalysts, including enzymes and metabolically engineered cells, has attracted a great deal of attention in the chemical and bio-industry, because biocatalytic reactions can be conducted under environmentally-benign conditions and in more sustainable ways. The catalytic efficiency and chemo-, regio-, and stereo-selectivity of enzymes can be enhanced and modulated using protein engineering. Metabolic engineering seeks to enhance cellular biosynthetic productivity of target metabolites via controlling and redesigning metabolic pathways using multi-omics analysis, genome-scale modeling, metabolic flux control, and reconstruction of novel pathways. The aim of this book is to cover the recent advances in biocatalysis and metabolic engineering for biomanufacturing of biofuels, chemicals, biomaterials, and pharmaceuticals. Reviews and original research articles on the development of new strategies to improve the catalytic efficiency of enzymes, biosynthetic capability of cell factories, and their applications in production of various bioproducts and chemicals are included.
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Keywords
- (?)-?-bisabolol
- 12-hydroxydodecanoic acid
- 3-hydroxypropionic acid
- 5-hydroxymethylfurfural
- ?-aminododecanoic acid
- acetate
- aerobic methane bioconversion
- amyloglucosidase
- artificial self-sufficient P450
- bio-hydrogen
- Biocatalysis
- biocatalysts
- biocatalytic reaction
- Biochemical engineering
- Biofilm
- Bioplastics
- Bioreactor
- Biotechnology
- bovine serum albumin
- Candida antarctica Lipase B
- cascade reactions
- chemicals addition
- Combi-CLEAs
- Corynebacterium glutamicum
- cross-linked enzyme aggregate
- CYP153A
- C–H activation
- dodecanoic acid
- enzyme modulation
- enzyme stabilization
- Eversa
- expression vectors
- fatty acid synthesis
- fed-batch fermentation
- fluorescein diacetate
- FTIR spectroscopy
- glyoxal oxidase
- hydrogenase
- immobilization
- interfacial activation
- lipase immobilization
- Magnetic nanoparticles
- mannose
- mass transfer performance
- MEP pathway
- Metabolic Engineering
- Methanosarcina mazei
- Methylosinus sporium strain 5
- MEV pathway
- mevalonate (MVA)
- mevalonate kinase 1
- microbial cell factory
- microbial production
- monoterpene
- Myceliophthora
- n/a
- Nylon 12
- O2 activation
- poly(ethylene glycol)
- polyethyleneimine
- polymer functionalization
- polyurethane foam
- prokaryotic microbial factory
- Pvgb
- redox enzymes
- review
- small molecules
- soluble methane monooxygenase
- specific recognition
- starch hydrolysis
- string film reactor
- Synthetic Biology
- synthetic metabolic pathways
- Technology, engineering, agriculture
- tetraethylene glycol
- total enzymatic activity
- transesterification
- tunable expression system
- vgb
- Vitreoscilla
- whole cell
- whole-cell biotransformation
Links
DOI: 10.3390/books978-3-03921-575-1Editions
