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Recent Progress in Solid Dispersion Technology
Kohsaku Kawakami
2019
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Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.
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Keywords
- accelerated stability test
- amorphisation
- amorphous
- amorphous polymeric salt
- amorphous solid dispersion
- amorphous solid dispersions
- anticancer drugs
- ball milling
- bicaludamide
- bioavailability
- Characterization
- ciprofloxacin
- Classification
- continuous processing
- Crystallization
- crystallization tendency
- dissolution
- dissolution enhancement
- dissolution rate
- enrofloxacin
- evaporation
- granulation
- hot melt extrusion
- Interaction
- intrinsic dissolution rate
- manufacturing methods
- mesoporous
- milling
- miscibility
- molecular complex
- molecular dynamics simulation
- nanoaggregates
- Nucleation
- pharmaceutical glass
- phase diagram
- poloxamer
- polyelectrolyte excipient matrix
- polyelectrolytes
- polymer
- poorly soluble drugs
- process development
- rebamipide
- self-assembly
- solid dispersion
- solid dispersions
- solubility
- solubility enhancement
- spectroscopic techniques
- spray drying
- Stability
- tadalafil
- thermal analysis
- thermodynamic modeling
- Weibull dissolution model
- Wood’s apparatus
Links
DOI: 10.3390/books978-3-03921-502-7Editions
