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Recent Progress in Solid Dispersion Technology

Recent Progress in Solid Dispersion Technology

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Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

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Keywords

  • accelerated stability test
  • amorphisation
  • amorphous
  • amorphous polymeric salt
  • amorphous solid dispersion
  • amorphous solid dispersions
  • anticancer drugs
  • ball milling
  • bicaludamide
  • bioavailability
  • Characterization
  • ciprofloxacin
  • Classification
  • continuous processing
  • Crystallization
  • crystallization tendency
  • dissolution
  • dissolution enhancement
  • dissolution rate
  • enrofloxacin
  • evaporation
  • granulation
  • hot melt extrusion
  • Interaction
  • intrinsic dissolution rate
  • manufacturing methods
  • mesoporous
  • milling
  • miscibility
  • molecular complex
  • molecular dynamics simulation
  • nanoaggregates
  • Nucleation
  • pharmaceutical glass
  • phase diagram
  • poloxamer
  • polyelectrolyte excipient matrix
  • polyelectrolytes
  • polymer
  • poorly soluble drugs
  • process development
  • rebamipide
  • self-assembly
  • solid dispersion
  • solid dispersions
  • solubility
  • solubility enhancement
  • spectroscopic techniques
  • spray drying
  • Stability
  • tadalafil
  • thermal analysis
  • thermodynamic modeling
  • Weibull dissolution model
  • Wood’s apparatus

Links

DOI: 10.3390/books978-3-03921-502-7

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