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Dual Specificity Phosphatases
Rafael Pulido and Roland Lang
2019
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Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.
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Keywords
- Asthma
- Astrocytes
- atypical dual-specificity phosphatases
- atypical DUSP
- BDNF
- brain metastasis
- Cancer
- Cannabinoids
- circulating tumor cells (CTCs)
- COPD
- Cpp1
- Cytokines
- DEPArray
- differentiation
- dual-specificity phosphatase
- dual-specificity phosphatases
- DUSP-4
- DUSP10
- E. coli infection
- fungal MKPs
- granule neurons
- HDAC6 (histone deacetylase isoform 6)
- hematopoietic cells
- HER2
- hypertriglyceridemia
- Inflammation
- Influenza
- integrated omics analysis
- liver steatosis
- macrophage
- Macrophages
- MAP Kinase Phosphatase-2
- MAP kinase phosphatases
- MAP kinases
- MAPK
- MAPK phosphatase
- MAPKs
- Microtubules
- mitogen-activated protein kinase
- MK-STYX (MAPK (mitogen-activated protein kinase) phosphoserine/threonine/tyrosine-binding protein)
- Mkp-1
- Msg5
- n/a
- Neuroblastoma
- neuronal differentiation
- nucleotide receptors
- P2X7
- P2Y13
- Pmp1
- Post-translational modification
- proliferation
- protein stability
- pseudophosphatase
- respiratory viruses
- rhinovirus
- RSV
- Sdp1
- Sepsis
- signaling
- single cell analysis
- T cell
- TLR signaling
- triple-negative breast cancer (TNBC)
- Ubiquitination
Links
DOI: 10.3390/books978-3-03921-689-5Editions
