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Transmucosal Absorption Enhancers in the Drug Delivery Field
Luca Casettari, Sam Maher, Lisbeth Illum
2020
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Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
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Keywords
- absorption enhancement
- absorption enhancer
- absorption enhancers
- absorption modifying excipients
- Aloe vera
- Amino acid
- amphiphilic polymers
- and liposome
- antiepileptic drug
- antimicrobial peptide
- biocompatibility studies
- bioenhancer
- block copolymers
- brush border
- Caco-2
- caco-2 cells
- cationic functionalization
- cell-penetrating peptide
- cell-penetrating peptide (CPP)
- cervicovaginal tumors
- chitosan
- chitosan derivatives
- claudin
- Clinical Trial
- CNS disorders
- combined microsphere
- compound 48/80
- confocal laser scanning microscopy
- cornea
- curcumin
- cyclodextrin
- Cytochrome P450
- drug absorption enhancer
- drug administration
- Drug delivery
- efflux
- enterocyte
- epithelial permeability
- epithelial transport
- Epithelium
- F-actin
- FITC-dextran
- formulation
- gel
- gemini surfactant
- GLP-1
- hydrophobization
- imatinib
- in situ hydrogel
- in vivo studies
- Insulin
- intestinal absorption
- intestinal delivery
- intestinal epithelial cells
- intestinal permeation enhancers
- KLAL
- Man
- mast cell activator
- medicine
- Metabolism
- mucoadhesion
- mucoadhesiveness
- N-dodecyl-?-D-maltoside (DDM)
- Nanocapsules
- Nanocrystals
- Nanomedicine
- nanoparticle
- Nanoparticles
- nasal
- nasal delivery
- nasal formulation
- nasal permeability
- nasal vaccination
- nose to brain delivery
- nose to brain transport
- nose-to-brain
- ocular conditions
- ocular delivery
- ocular drug delivery
- Ophthalmology
- oral delivery
- oral macromolecule delivery
- oral peptides
- osteoporosis
- P-Glycoprotein
- penetration enhancer
- penetration enhancers
- Permeability
- permeation enhancer
- permeation enhancers
- pharmacokinetic interaction
- pharmacokinetics
- PN159
- polymeric micelles
- poorly absorbed drug
- preclinical
- PTH 1-34
- pulmonary
- quaternization
- Safety
- salcaprozate sodium
- Sheep
- simulated intestinal fluid
- simvastatin
- small intestine
- sodium caprate
- sodium cholate (NaC)
- sugar-based surfactants
- teriparatide
- thermogel system
- tight junction
- tight junction modulator
- Tight Junctions
- transepithelial electrical resistance
- transferrin
- transmucosal drug delivery
- transmucosal permeation
- tryptophan
- vaccine adjuvant
- vaginal delivery
- whole leaf
Links
DOI: 10.3390/books978-3-03921-849-3Editions
