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Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice.
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Keywords
- Adipokine
- adipokines
- adiponectin
- Adipose Tissue
- adipose-brain axis
- alpha-fetoprotein
- annexins
- biologic activity
- biomarker
- brain health
- C-C chemokine receptor-like 2
- Cancer
- Cardiovascular Diseases (CVDs)
- cathepsins
- chemerin
- chemerin receptors
- chemokine-like receptor 1
- cholesterol
- complement factors
- Critical Illness
- Depression
- early pregnancy
- early-life programming
- Energy Metabolism
- EP3 receptor
- EP4 receptor
- epicardial adipose tissue (EAT)
- excessive gestational weight gain
- exchange protein directly activated by cAMP isoform 2 (EPAC2)
- extracellular remodeling
- fat mass
- fatty liver
- fitness
- follicular fluid
- free fatty acids
- G protein-coupled receptor 1
- gestational diabetes
- Ghrelin
- glucose homeostasis
- glucose restriction
- human granulosa cells
- Hypertension
- Hypothalamus
- ICU
- in vitro fat regain
- Inflammation
- Insulin
- interleukin(IL)-33
- label-free proteomic profiling
- Leptin
- leukocyte
- Lipid Metabolism
- Lipids
- liver steatosis
- medicine
- metabolically healthy obese
- Microglia
- myokine
- n/a
- neonatal anthropometry
- neurodegeneration
- nonalcoholic fatty liver disease
- Obesity
- oestrous cycle
- Osteoarthritis
- ovary
- PCOS
- pig
- polycystic ovary morphology
- Polycystic Ovary Syndrome
- preeclempsia
- prognosis
- prostaglandin E2 (PGE2)
- proteolysis
- resistin
- Rheumatic Diseases
- Rheumatoid arthritis
- secreted frizzled-related protein 5
- Sepsis
- SGBS adipocytes
- sick fat
- stimulating growth factor 2 (ST2)
- Tango bioassay
- testicular pathologies
- testis
- tocilizumab
- triglycerides
- visceral fat
- weight regain
Links
DOI: 10.3390/books978-3-03928-587-7Editions
