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Circulating Tumor Cells

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The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.

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Keywords

  • abiraterone
  • ACCEPT
  • androgen receptor
  • AR
  • AR-V7
  • ARV7
  • biomarker
  • biomarkers
  • Bone Marrow
  • Breast cancer
  • castration resistant prostate cancer (CRPC)
  • CD133
  • CellSearch
  • CellSearch®
  • cerebrospinal liquid biopsy
  • chemoradioresistance
  • chromogranin A
  • circulating leukemia cells
  • circulating plasma cells
  • circulating tumor cells
  • circulating tumor cells (CTC)
  • circulating tumor cells (CTCs)
  • circulating tumor DNA
  • circulating tumour cells
  • clinical trials
  • clinical utility
  • colorectal cancer
  • Colorectal Surgery
  • CTC
  • CTC biology
  • CTC capture technology
  • CTC-based treatment decisions
  • CTC-derived ex vivo models
  • CTC-derived xenografts
  • CTCs
  • ctDNA
  • CTM
  • CTMat
  • ctRNA
  • disseminated tumor cells
  • early breast cancer
  • EasyCount slides
  • emboli
  • enrichment and detection technologies
  • enzalutamide
  • EpCAM enrichment
  • EPISPOT
  • Epithelial-to-mesenchymal transition (EMT)
  • epithelial–mesenchymal transition
  • exosome
  • Exosomes
  • fibronectin
  • fish
  • Flow Cytometry
  • FOLFIRINOX
  • gene expression analysis
  • Glioma
  • hematological cells
  • hepatocellular carcinoma (HCC)
  • heterogeneity
  • HMB-45
  • immune checkpoint inhibitors
  • Immune system
  • immunofluorescence imaging
  • Immunomodulation
  • immunophenotyping
  • in vivo flow cytometry
  • integrin B1
  • leukocyte-derived extracellular vesicles
  • Liquid Biopsy
  • liquid surgery
  • locally advanced rectal cancer
  • major histocompatibility complex class I (MHCI)
  • Malaria
  • Melanoma
  • metastasis
  • metastatic colorectal cancer
  • microbiome
  • Microfluidics
  • microsatellite instability
  • miRNA
  • n/a
  • Neutrophils
  • NSCLC
  • PD-L1 expression
  • platelets
  • prostate cancer
  • prostate cancer (PCa)
  • RAD23B
  • rovalpituzumab tesirine
  • rVAR2
  • single-cell analysis
  • SLUG
  • small-cell lung carcinoma
  • solid cancers
  • Stem Cells
  • synaptophysin
  • targeted therapy
  • thymidylate synthase
  • tumor biomarkers
  • tumor cell dissemination
  • tumor stem cells
  • tumor-initiating cells (TICs)
  • xenograft models

Links

DOI: 10.3390/books978-3-03928-699-7

Editions

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