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New Insights into Parvovirus Research

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Viruses in the Parvoviridae family constitute one of the most diverse and intriguing fields of research. While they all share an ssDNA genome and a small capsid, they can differ widely in structure, genome organization and expression, virus–cell interaction, and impact on the host. Exploring such diversity and unraveling the inherent complexity in these apparently simple viruses is an ongoing endeavor and commitment for the scientific community. The translational implications of research on parvoviruses are relevant. Within the family, some viruses are important human and veterinary pathogens, in need of diagnostic methods and antiviral strategies; other viruses have long been studied and engineered as tools for oncolytic therapy, or as sophisticated gene delivery vectors, and can now display their wide and expanding applicative potential. This Special Issue of Viruses collects recent contributions in the field of parvovirus research, with a focus on new insights and research on unresolved issues, as well as new approaches exploiting systemic methodologies. Evolution, structural biology, viral replication, virus–host interaction, pathogenesis and immunity, and viral oncotherapy are a selection of the topics addressed in the issue that can be of relevance to the community involved in parvovirus research and of interest to a wider audience.

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Keywords

  • AAV
  • AAV2
  • acute gastroenteritis
  • adeno-associated virus
  • adenoviral vector
  • Agricultural pests
  • alpaca
  • anti-cancer
  • antibody interactions
  • antiviral compounds
  • antivirals
  • Apoptosis
  • arthropod
  • B19V
  • biocontrol
  • BIRC3 (cIAP-2)
  • bisulfite PCR
  • Bocaparvovirus
  • Bombyx mori bidensovirus
  • brincidofovir
  • canine chapparvovirus
  • canine parvovirus
  • capsid stability
  • Carnivore protoparvovirus 1
  • caspase-3
  • cell cycle arrest
  • chapparvovirus
  • Children
  • chitin
  • cidofovir
  • circulating angiogenic cells
  • clinical trials
  • combination therapies
  • commercial horse serum
  • coumarin derivatives
  • CpG methylation
  • Cryo-EM
  • densovirus
  • Diagnosis
  • dilated cardiomyopathy
  • divalent cations
  • DNA virus
  • endogenous viral elements
  • equine parvovirus-hepatitis
  • erythroid progenitor cells
  • erythrovirus
  • Evolution
  • feline panleukopenia virus
  • Flavonoids
  • Genetics
  • Genome
  • genome externalization
  • glycans
  • H-1PV
  • homology modeling
  • Horses
  • human airway epithelia
  • human bocavirus
  • human bocavirus 1
  • hydroxyurea
  • Immunomodulation
  • inflammatory cardiomyopathy
  • insect
  • insect parvovirus
  • intravenous immunoglobulin (IVIG)
  • Lepidoptera
  • Metagenomics
  • mite
  • myocarditis
  • new viruses
  • next-generation sequencing
  • NS1
  • NS2
  • nuclear targeting
  • oncolytic activity
  • oncolytic virus immune therapy
  • oncolytic viruses
  • overlapping promoters
  • Parvoviridae
  • parvovirus
  • parvovirus B19
  • parvovirus evolution
  • peritrophins
  • phospholipase-A2
  • phylogeny
  • PLA2
  • preclinical
  • prognosis
  • protease
  • Race
  • receptor interactions
  • RNA-Seq
  • rodent protoparvoviruses
  • RT-qPCR
  • second generation parvovirus treatments
  • sequence analysis
  • single stranded DNA virus
  • structural biology
  • telbivudine
  • trafficking
  • transcription mapping
  • transcription profile
  • Tumor microenvironment
  • uncoating
  • viral communities
  • Viral ecology
  • viral metagenomics
  • virus
  • virus diversity
  • virus phylogeny
  • X-ray crystallography

Links

DOI: 10.3390/books978-3-03928-311-8

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