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PLGA Based Drug Carrier and Pharmaceutical Applications
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Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.
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Keywords
- 17-βestradiol release
- Activation
- aggregation
- alginate
- binding
- biodegradable polymers
- BMP-2
- BMP-2-microspheres
- Bone Regeneration
- Cancer
- cellular uptake
- CHO-K1 cells
- cisplatin
- colorectal cancer
- controlled drug release
- controlled release
- Core-shell nanoparticles
- dexamethasone
- double emulsion approach
- Drug delivery
- Drug delivery systems
- drug release
- Electron microscopy
- electroporation
- Experimental design
- folic acid
- formulation development
- fractional factorial design
- gadolinium
- gastrointestinal tract
- glioblastoma multiforme
- Huntington’s disease
- hydrogel
- hydrogel system
- hydroxy-stearic acid
- in vivo imaging
- intra-abdominal anti-adhesion barrier
- intra-articular injection
- joint retention
- led
- local delivery
- Magnetic Resonance Imaging
- magnetic targeting
- medicine
- Mesenchymal Stromal Cells
- microcapsules
- microcarriers
- microcrystal
- Microfluidics
- microparticles
- microsphere
- microspheres
- molecular mobility
- multimodal imaging
- n/a
- nano-CT
- Nanomedicine
- Nanoparticles
- nanoscaled drug delivery
- NSAIDs
- O6-methylguanine DNA methyltransferase (MGMT) protein
- oleogels
- ophthalmic drug delivery
- osteoporosis
- oxaliplatin
- paclitaxel
- Photoluminescence
- PLA
- platelet
- PLGA
- PLGA microsphere
- PLGA nanocapsules
- PLGA nanoparticles
- PLGA-NPs
- PLGA-PEG
- Pluronic F68
- poly-lactide-co-glycolide
- polylactic acid
- polymeric film
- polymeric nanocarrier
- Reactive Oxygen Species
- risperidone
- serum stability
- Silicon
- siRNA
- SKOV-3 cells
- smart nanocarriers
- sorafenib
- spray-drying technique
- systemic exposure
- terahertz spectroscopy
- theranostic cargo
- theranostic nanoparticles
- theranostics
- three-dimensional X-ray imaging
- Tissue Engineering
- tocopherol
- topical drug delivery
- triamcinolone acetonide
- trolamine salicylate
- uptake
- verteporfin
- Vitamin E
Links
DOI: 10.3390/books978-3-0365-0221-2Editions