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Role of Genomics in the Management of Hypertension
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Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field.
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Keywords
- adducin
- African American
- Aldosterone
- aldosterone-producing adenoma
- ARMC5
- atrial natriuretic peptide
- Biology, Life Sciences
- Blood pressure
- burden test
- CACNA1D
- cardiac hypertrophy
- cardio-tonic steroids
- Cardiovascular Diseases
- cervical artery dissection
- CRY1
- CRY2
- DNA Methylation
- endocrine hypertension
- endogenous ouabain
- endothelial cells
- endothelial dysfunction
- epigenetics
- essential hypertension
- exome microarray
- fibromuscular dysplasia
- genetic association
- Genetics
- genetics of left ventricular hypertrophy
- genome-wide association studies
- GRK4
- Heart Failure
- Histone Modifications
- HSD3B1
- HSD3B2
- Hypertension
- hypokalemia
- Kruppel-like factor 15
- left ventricular hypertrophy
- Liddle syndrome
- low renin hypertension
- low-renin
- Mathematics & science
- micro RNA
- mineralocorticoid receptor
- monogenic hypertension
- next-generation sequencing
- non atherosclerotic vascular stenosis
- non-coding RNA
- PHACTR1
- platelet aggregation
- primary aldosteronism
- rare variants
- rare-variants association testing
- Reference, information & interdisciplinary subjects
- renal damage
- renin
- Research & information: general
- SCNN1A
- SCNN1B
- SCNN1G
- sequence kernel association test
- smooth muscle cells contraction
- spontaneous coronary arteries dissection
- T2238C variant
- transcriptome profiing
- vascular smooth muscle cells
Links
DOI: 10.3390/books978-3-03936-628-6Editions