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Antiviral agents are used for the treatment of viral diseases. Antiviral drugs have been successfully developed and used clinically for a limited number of important human viral diseases notably caused by human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), herpes, and influenza viruses. Despite the successes of these antiviral drugs, issues with drug resistance and toxicity remain challenging. These challenges are driving research to identify new drug candidates and to investigate novel drug targets to develop new mechanistic drug classes. Antiviral agents are not available against many viruses that cause human disease and economic burdens; in particular, the development of antiviral agents against emerging, re-emerging, and neglected viruses is increasingly becoming a priority. This book includes six review articles that discuss new antiviral strategies. The reviews either discuss advances relating to a specific virus or new therapeutic targets and approaches. The book includes 15 original research articles reporting new antiviral agents against a variety of clinically and economically important viruses and studies into the prevalence or acquisition of drug resistance. Overall, this book is an exciting collection of new research and ideas relating to the development of antiviral agents.
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Keywords
- acteoside
- acute/latent infection
- acyclovir
- adoptive cell therapy
- antipsychotic drug
- antiviral
- antiviral activity
- antiviral agent
- antiviral agents
- antiviral drug
- antiviral effect
- antiviral inhibitor
- antiviral strategies
- Biology, Life Sciences
- branched peptides
- brevilin A
- Burkitt lymphoma cells
- C-FRA
- cathelicidins
- Central nervous system
- chemical footprinting
- Clerodendrum trichotomum
- clozapine
- combination antiretroviral therapy (cART)
- congenital infection
- Coxsackievirus B4
- CRISPR/Cas
- Cytomegalovirus
- defensins
- dried blood spots
- dried plasma spots
- Drug Discovery
- Endocytosis
- enteroviruses
- epigallocatechin gallate
- Epstein–Barr virus
- Ethiopia
- Flavivirus
- Flavonoids
- fluoxetine
- furin inhibitor
- ganciclovir
- genistein
- ginsenoside Rg1
- glycosphingolipids
- HCMV vaccine
- hemagglutinin (HA)
- Heparan sulfate
- Hepatitis C virus
- hepcidins
- herpes B virus
- herpes viruses
- Herpesvirus
- HIV
- human antimicrobial peptides
- human immunodeficiency virus
- ie-1 gene
- IE1
- IE2
- immediate-early
- Influenza A virus
- Influenza A virus (IAV)
- Japanese encephalitis virus
- latent infection
- lectin
- lipid biosynthesis
- LUMS1
- lytic gene expression
- macacine herpesvirus-1
- Mathematics & science
- measles virus
- microvirin
- Mutations
- n/a
- Neural Stem Cells
- NF-κB signaling pathway
- non-immunogenic
- NS5
- nucleic acid-based therapeutic approach
- nucleoside analogues
- oleanane-type derivatives
- orthohantavirus
- Pediatrics
- PEI
- persistent infection
- phenyl-benzotriazoles
- Plantago asiatica
- polyethylenimine
- Porcine circovirus type 2
- porcine reproductive and respiratory syndrome virus
- pre-treatment drug resistance
- precursor membrane protein
- pro-inflammatory factor
- prodrugs
- protein drugs
- ProTides
- PRRSV
- quantitative real-time PCR
- Reference, information & interdisciplinary subjects
- replication
- Research & information: general
- Resistance
- Rev response element
- ribozyme
- RNA interference
- RNA-dependent RNA polymerase
- RSV
- sesquiterpene lactone
- Shape
- small molecule
- sphingolipids
- Surveyor nuclease mutation detection assay
- TALEN
- therapeutic effects
- therapeutic strategies
- transferrins
- treatments
- tropism
- viral entry
- virion internalization
- virus attachment
- virus entry inhibitors
- Viruses
- Zika virus
Links
DOI: 10.3390/books978-3-03928-954-7Editions