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Cocrystal Applications in Drug Delivery
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In 2015, the first pharmaceutical cocrystal was approved by the FDA. Since then, the number of cocrystals on the market and in the development pipeline has been slowly but steadily growing. It is now well established that cocrystals are a versatile new approach to oral drug formulation. This Reprint Book is a collection of articles that show the utility of pharmaceutical cocrystals and various aspects of cocrystal research: • Cocrystals as a strategy to modify the physicochemical properties of a drug such as dissolution behaviour, tabletability, and melting point; • Development of new coformers; • Screening studies for multiple cocrystal forms; • Cocrystals in nano-sized drug delivery.
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Keywords
- barbituric acid
- cocrystal
- cocrystals
- compaction
- Crystal engineering
- Crystal structure
- crystallization inhibitors
- Design of experiments
- diclofenac sodium
- dissolution
- dissolution behavior
- dissolution rate
- drug-polymer interactions
- formulation
- HIV/AIDS
- imidazole N-oxides
- interparticulate bonding area
- interparticulate bonding strength
- itraconazole
- L-proline
- lamivudine
- mechanochemistry
- monohydrate
- multicomponent crystal
- multicomponent crystals
- n/a
- nano co-crystals
- nanoindentation
- nefiracetam
- nitazoxanide
- particle size
- pharmaceutical cocrystals
- polydispersity index
- quality by design
- Reference, information & interdisciplinary subjects
- Research & information: general
- salt cocrystal
- slip plane
- Solid State
- solid state NMR
- solid-state
- solubility
- sonochemistry
- Stability
- supersaturated formulations
- surface topology
- tabletability
- terephthalic acid
- tetrahydrate
- thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
- thermal analysis
- thiobarbituric acid
- wettability
- X-ray diffraction
- zeta potential
- zidovudine
Links
DOI: 10.3390/books978-3-03943-984-3Editions