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Diagnosis and Treatment of Small Bowel Disorders
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Over the last few decades, remarkable progress has been made in understanding the aetiology and pathophysiology of diseases and many new theories emphasize the importance of the small bowel ‘ecosystem’ in the pathogenesis of acute and chronic illness. Emerging factors such as microbiome, stem cells, innate intestinal immunity and the enteric nervous system along with mucosal and endothelial barriers have key role in the development of gastrointestinal and extra-intestinal diseases. Therefore, the small intestine is considered key player in metabolic disease development, including diabetes mellitus, and other diet-related disorders such as celiac and non-celiac enteropathies. Another major field is drug metabolism and its interaction with microbiota. Moreover, the emergence of gut-brain, gut-liver and gut-blood barriers points toward the important role of small intestine in the pathogenesis of common disorders, such as liver disease, hypertension and neurodegenerative disease. However, the small bowel remains an organ that is difficult to fully access and assess and accurate diagnosis often poses a clinical challenge. Eventually, the therapeutic potential remains untapped. Therefore, it is due time to direct our interest towards the small intestine and unravel the interplay between small-bowel and other gastrointestinal (GI) and non-GI related maladies.
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Keywords
- Adult Stem Cells
- adverse events
- Biology, Life Sciences
- biomarker
- biomedical optical imaging
- cancer risk
- capsule endoscopy
- celiac disease
- clinical diagnosis
- collagenous colitis
- colon cancer
- Crohn’s disease
- cystic fibrosis
- dysbiosis index
- enteropathy
- fecal calprotectin
- functional gastrointestinal disorders
- Gastroenterology
- gut brain axis
- Gut Microbiota
- hyperspectral imaging
- Inflammatory Bowel Disease (IBD)
- intestinal inflammation
- lung cancer
- Mathematics & science
- medical diagnostic imaging
- Meta-analysis
- microbiota
- microscopic colitis
- mucosal healing
- Multispectral Imaging
- n/a
- Prebiotics
- Probiotics
- Reference, information & interdisciplinary subjects
- Research & information: general
- Serology
- skin cancer
- small bowel
- small-bowel bulge
- small-bowel mass
- squamous cell carcinoma
- Surgery
- surgical site infections (SSIs)
- synbiotics
- systematic review
- video capsule endoscopy
Links
DOI: 10.3390/books978-3-03943-874-7Editions