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Hedgehog Signaling in Organogenesis and Tumor Microenvironment
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The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers’ drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling.
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Keywords
- androgen
- animal experiment
- articular disc
- basement membrane
- bone
- bone disease
- bone morphogenetic protein
- cancer stem cells
- cancer-associated fibroblasts (CAFs)
- chondrocyte
- congenital anomalies
- CRE/LoxP
- Cyp26 enzymes
- endochondral ossification
- epithelial and mesenchymal interaction
- epithelial–mesenchymal interaction (EMI)
- external genitalia
- fracture healing
- Gli1
- growth plate
- hedgehog
- hedgehog signaling
- hedgehog signalling
- hypospadias
- Ihh
- lineage tracing analysis
- medicine
- mesenchymal stem cell
- mouse models
- n/a
- oral squamous cell carcinoma (OSCC)
- Osteoarthritis
- osteoblast
- Penis
- prostate cancer
- PTHrP
- Retinoic acid
- smoothened
- sonic hedgehog
- sonic hedgehog (SHH)
- stem cell
- stem cell marker
- synovial joint
- TMJ
- tooth development
- tumor microenvironment (TME)
- tumor-associated angiogenesis
- tumor-associated macrophages (TAMs)
- urethra
Links
DOI: 10.3390/books978-3-03936-261-5Editions