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New Aspects of Cancer Stem Cell Biology
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The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on “New aspects of cancer stem cell biology: implications for innovative therapies” aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies.
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Keywords
- ALDH1
- ATAC-seq
- B4GALT1
- bevacizumab
- Biology, Life Sciences
- bowel cancer
- Breast cancer
- Cadherin 11
- Cancer stem cell
- cancer stem cells
- cancer therapy
- cell adhesion molecule
- chemo-resistance
- chemoresistance
- chemotherapy resistance
- colon
- colorectal
- CSCs
- dasatinib
- early breast cancer
- EC-8042
- Epithelial-Mesenchymal Transition
- Exosomes
- Genetic Heterogeneity
- genome-wide
- HDAC inhibitors
- head and neck squamous cell carcinoma
- immunohistochemistry
- L1CAM
- Lipid
- LUAD
- lung cancer
- Mathematics & science
- Metabolism
- neoadjuvant chemotherapy
- NSCLC
- oral cancer risk
- oral epithelial dysplasia
- oral squamous cell carcinoma
- organoid
- ovarian cancer
- Reference, information & interdisciplinary subjects
- Research & information: general
- RNA-Seq
- saracatinib
- SNP array
- solid cancer
- SOX2
- src
- stem cell
- therapeutic resistance
- therapy resistance
- TNBC
- transcriptome
- tumor progression
- tumoroid
- Wnt signaling
- β-catenin
Links
DOI: 10.3390/books978-3-03943-407-7Editions