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<em>Mycobacterium tuberculosis</em> Pathogenesis, Infection Prevention and Treatment
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Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) and it represents a persistent public health threat for a number of complex biological and sociological reasons. According to the most recent Global Tuberculosis Report (2019) edited by the World Health Organization (WHO), TB is considered the ninth cause of death worldwide and the leading cause of mortality by a single infectious agent, with the highest rate of infections and death toll rate mostly concentrated in developing and low-income countries. We present here the editorial section to the Special Issue entitled “Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment” that includes 7 research articles and a review. The scientific contributions included in the Special Issue mainly focus on the characterization of MTB strains emerging in TB endemic countries as well as on multiple mechanisms adopted by the bacteria to resist and to adapt to antitubercular therapies.
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Keywords
- antitubercular drug discovery
- antitubercular treatments
- Apoptosis
- Beijing B0/W148
- Beijing genotype
- Biology, Life Sciences
- BM-MSCs
- bone-homing
- CD38
- Central Asia Outbreak
- cytokine
- Drug Discovery
- drug resistance
- Drug Target
- effector
- efflux
- Gene expression
- HLA-DR
- Host-Pathogen Interactions
- IL-18
- IL-18BP
- IL-18R
- immune activation
- Immune response
- latent tuberculosis
- line probe assay
- liposomes
- M. tuberculosis
- macrophage
- Mathematics & science
- MDR-TB
- microRNA
- MmpS5-MmpL5
- Mtb
- murine infection model
- Mycobacterium
- Mycobacterium avium
- Mycobacterium smegmatis
- Mycobacterium tuberculosis
- omics analysis
- pre-XDR-TB
- Reference, information & interdisciplinary subjects
- relapse
- Research & information: general
- second-line drugs
- Stem Cell Niche
- subtractive genomics
- System analysis
- TB treatment
- treatment response
- Tuberculosis
- uncharacterized proteins
- unique metabolic pathways
- Virulence
- XDR-TB
Links
DOI: 10.3390/books978-3-03936-659-0Editions