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Enzyme Inhibitor from Marine Organisms
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Marine habitats are promising sources to identify novel organisms and compounds. A total of 70% of the planet’s surface is covered by ocean, and little is known about the biosphere within these habitats. In the last few years, numerous novel bioactive compounds or secondary metabolites from marine environments have been described. This is, and will be, a promising source of candidate compounds in pharma research and chemical biology. In recent years, a number of novel techniques have been introduced to the field and it has become easier to actually (bio-)prospect compounds such as enzyme inhibitors. Those novel compounds then need to be characterized and evaluated in comparison to well-known representatives. This Special Issue focuses on the description of novel enzyme inhibitors of marine origin, including bioprospecting, omic approaches, and structural and mechanistic aspects.
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Keywords
- ACE inhibitory peptide
- acetylcholinesterase
- Alzheimer′s disease
- asperchalasine
- BACE1
- bioactives
- Drug development
- enzyme inhibition
- functional annotation
- GH109 α-N-acetylgalactosaminidase
- GH36 α-galactosidase
- in silico docking
- inactivation
- inhibitor
- kinase inhibitors
- macroalgae
- marine bacteria
- marine fish
- marine fungi
- Marine Natural Products
- marine sponges
- molecular docking
- monanchomycalin B
- monanhocidin A
- Mycosphaerella sp.
- Natural Products
- normonanhocidin A
- optimization
- pentacyclic guanidine alkaloids
- phlorotannins
- protease
- Purification
- Reference, information & interdisciplinary subjects
- Research & information: general
- secondary metabolites
- slow-binding irreversible inhibitor
- sponge Monanchora pulchra
- structural identification
- structure–function relation
- thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
- Ulva intestinalis
- Ulva ohnoi
- α-glucosidase
Links
DOI: 10.3390/books978-3-03943-784-9Editions