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Oligodendrocyte Physiology and Pathology Function
Markus Kipp (editor)
2021
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The adult vertebrate central nervous system mainly consists of neurons, astrocytes, microglia cells, and oligodendrocytes. Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which multiple sclerosis (MS) is included. This disease is associated with the development of large demyelinated plaques, oligodendrocyte destruction, and axonal degeneration, paralleled by the activation of astrocytes and microglia as well as the recruitment of peripheral immune cells to the site of tissue injury. Of note, viable oligodendrocytes and an intact myelin sheath are indispensable for neuronal health. For example, it has been shown that oligodendrocytes provide nutritional support to neurons, fast axonal transport depends on proper oligodendrocyte function, and mice deficient in mature myelin proteins eventually display severe neurodegeneration. This Special Issue contains a collection of highly relevant primary research articles as well as review articles focusing on the development, physiology, and pathology of the oligodendrocyte–axon–myelin unit.
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Keywords
- 18F-FDG
- Age
- astrocyte
- Astrocytes
- Atrophy
- Biology, Life Sciences
- caffeine
- CNS
- Cognition
- conditional knockout
- corpus callosum (CC)
- cre-recombinase
- cross-talk
- cuprizone
- cuprizone model
- Demyelination
- design-based stereology
- DigiGait™
- Down Syndrome
- Drug Screening
- EGFR inhibitor
- energy drinks
- epigenetics
- experimental autoimmune encephalomyelitis
- experimental autoimmune encephalomyelitis (EAE)
- gait analysis
- glial cells.
- glial fate
- glial progenitor cells
- immunohistochemistry
- interneuron
- laquinimod
- Life sciences: general issues
- liquid chromatography-mass spectrometry
- macromolecular proton fraction
- Magnetic Resonance Imaging
- Mathematics & science
- medicine
- microfibers
- Microglia
- MPF
- Multiple Sclerosis
- murine acute brain slices
- myelin
- Myelination
- n/a
- nanofibers
- neurodegeneration
- Neuron
- Neurosciences
- Nsun5
- oligodendrocyte
- oligodendrocyte (OL)
- oligodendrocyte precursors
- oligodendrocyte progenitor cells
- oligodendrocytes
- OPC
- plasma membrane proteins
- Pluripotent Stem Cells
- rat cerebellum
- remyelination
- reproducibility
- Schizophrenia
- screening
- smoothened agonist
- tamoxifen
- Taurine
- transient receptor potential ankyrin 1
- Treatment
- white matter
- white matter disease
- Williams-Beuren syndrome (WBS)
Links
DOI: 10.3390/books978-3-03943-690-3Editions