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Metastatic Progression and Tumour Heterogeneity
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Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.
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Keywords
- 3D cultures
- acidosis
- ADH
- angiocrine factor
- beta-catenin paradox
- Biomechanics
- Breast cancer
- carbonic anhydrase
- cell fate
- cellular heterogeneity
- circulating tumor cells
- circulating tumor cells (CTCs)
- clear cell renal cell carcinoma
- clonality
- collective and single-cell migration
- colon cancer
- colorectal cancer
- CTC-clusters
- DCIS
- deficient mismatch repair
- EMT
- endometrial carcinoma
- epigenetics
- epithelial mesenchymal plasticity
- epithelial-to-mesenchymal transition
- esophageal squamous cell carcinoma
- extracellular vesicles
- Gene expression
- Genomics
- heterogeneity
- hybrid E/M
- hyperpolarized 13C MRI
- immune checkpoints
- immune microenvironment
- Immunotherapy
- interstitial pH
- intra-tumour heterogeneity
- intratumor heterogeneity
- lactic acid
- Magnetic Resonance Imaging
- mammary gland
- medicine
- metaplastic carcinoma
- metastasis
- metastatic niche
- microsatellite instability
- miRNA expression
- multisite tumor sampling
- Mutation
- natural killer cells
- nuclear medicine
- organoids
- Pancreatic Cancer
- pet
- phenotypic plasticity
- PI3K/Akt pathway
- Plasticity
- positron emission tomography
- precision medicine
- radiomics
- Radiopharmaceuticals
- review
- signaling
- single-cell analysis
- single-cell RNAseq
- subclonal diversity
- SUV
- target discovery
- targeted therapy
- TP53
- treatment resistance
- tumor ecology
- tumor endothelial cell
- tumor evolution
- tumor heterogeneity
- Tumor microenvironment
- tumor mutation burden
- uterine carcinosarcoma
- Wnt signaling
Links
DOI: 10.3390/books978-3-03928-854-0Editions