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Role of Natural Bioactive Compounds in the Rise and Fall of Cancers

Role of Natural Bioactive Compounds in the Rise and Fall of Cancers

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Recent years have seen the idea of a close association between nutrition and the modulation of cancer development/progression reinforced. An increasing amount of experimental and epidemiological evidence has been produced supporting the concept that many different bioactive components of food (e.g. polyphenols, mono- and polyunsaturated fatty acids, methyl-group donors, etc.) may be implicated in either the promotion of or the protection against carcinogenesis. At the cellular level, such compounds can have an impact on different but sometimes intertwined processes, such as growth and differentiation, DNA repair, programmed cell death, and oxidative stress. In addition, compelling evidence is starting to build up of the existence of primary epigenetic targets of dietary compounds, such as oncogenic/oncosuppressor miRNAs or DNA-modifying enzymes, which in turn impair gene expression and function. Since there is a growing interest in the study of the biochemical and molecular role played by food components and its impact on cellular processes and/or gene expressions directed towards the fine-tuning of cancer phenotypes, in this Special Issue researchers contributed with either research or review articles presenting the latest findings on the intracellular pathways and mechanisms affected by natural bioactive dietary molecules.

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Keywords

  • acute myeloid leukemia
  • adipocyte inflammation
  • Akt
  • AMPK
  • Angiogenesis
  • anti-cancer drug
  • anti-proliferative
  • anticancer
  • anticancer activities
  • anticancer drug
  • anticancer drugs
  • AOM/DSS model
  • Apoptosis
  • Autophagy
  • berberine
  • Berthel.
  • bioactivities
  • bioavailability
  • Biology, Life Sciences
  • brain cancer
  • Breast cancer
  • breast cancer cells
  • breast cancer prognostic
  • breast cancer risk
  • Calocedrus formosana
  • Cancer
  • Cancer Metabolism
  • Cancer stem cell
  • cancer therapy
  • carrageenan
  • caspase-independent cell death
  • Cell Death
  • Cell signaling
  • cell-cycle arrest
  • chemoprevention
  • colchicine alkaloid
  • colon cancer
  • colon cancer cells
  • colorectal cancer
  • daidzein
  • daidzein metabolites
  • Drugs
  • EGCG
  • EGFR signaling
  • EGFR TKI
  • eicosapentaenoic acid
  • epigallocatechin-3-gallate (EGCG)
  • epithelial mesenchymal transition
  • ER stress
  • estrogen
  • estrogen receptor alpha
  • Ethanol
  • experimental therapeutics
  • FASN inhibitors
  • Flavonoids
  • formononetin
  • fucoidan
  • G2/M arrest
  • gallic acid
  • gemcitabine
  • gigantol
  • gliomas
  • glucose transport
  • Glycolysis
  • glycolytic markers
  • HDAC
  • HO-1
  • honokiol
  • human cancer cells
  • Immunotherapy
  • Inflammation
  • innate immunity
  • Invasion
  • isobolography
  • isorhamnetin
  • JAK/STAT
  • lung cancer
  • malignant cancer
  • malignant tumors of the peripheral nerve sheath (MPNST)
  • Malva pseudolavatera Webb &amp
  • mangrove
  • marine sponge
  • Mathematics & science
  • Mechanism
  • melanoma cells
  • mesoporous silica nanoparticles
  • metastasis
  • MicroRNAs
  • MMPs
  • molecular mechanisms
  • multiple myeloma
  • n/a
  • nanoparticle-based delivery systems
  • natural anti-inflammatory compounds
  • natural bioactive compound
  • natural compounds
  • natural polyphenols
  • natural product
  • neurofibromas
  • Nicotine
  • nobiletin
  • non-coding RNAs
  • Nrf2
  • NSCLC
  • Nutrition
  • Obesity
  • oleacein
  • oleuropein
  • olive leaf extract
  • oncogenic cascades
  • oral cancer inhibition
  • p53
  • paclitaxel
  • Pancreatic Cancer
  • PD-1 immune checkpoint inhibitor and cancer immunotherapy
  • PD-L1
  • persistent organic pollutants
  • phosphofructokinase
  • Phytochemicals
  • Piper eriopodon, alkenylphenols
  • Polyphenols
  • preclinical models
  • pro-resolving lipids
  • Proteomics
  • RacGAP1
  • Radiotherapy
  • Reactive Oxygen Species
  • Reference, information & interdisciplinary subjects
  • renin–angiotensin system
  • Research & information: general
  • Resistance
  • ROS
  • schwannomas
  • Seahorse analysis
  • signaling pathways
  • signalling pathway
  • small organic agents
  • STAT3
  • Streptomyces
  • systematic review
  • targeted delivery system
  • TRAIL
  • tumor density
  • tumor maintenance
  • uterine sarcoma
  • xenograft
  • Xenopus laevis
  • XIAP antagonists
  • XIAP-BIR3 domain
  • yatein
  • α9-nAChR
  • β-glucans

Links

DOI: 10.3390/books978-3-03943-293-6

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