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Asthma is a common complex and heterogeneous respiratory disease with an increasing prevalence in developed countries. Asthma is a disease consisting of different phenotypes that are driven by different mechanistic pathways (endotypes). The recognition of these phenotypes and endotypes is central to asthma management entailing prognostic and therapeutic implications. It is acknowledged that despite optimal treatment, many patients are poorly controlled, highlighting the need for phenotype-guided treatments. In this context, the emergence of novel therapies (monoclonal antibody therapy, bronchial thermoplasty) is paving the way for personalized asthma therapy. A better understanding of disease pathogenesis may enable the identification of biomarkers, mediators, novel therapeutic targets, and treatable traits. Further molecular phenotyping or endotyping of asthma will be necessary to tailor new therapeutic strategies. The present Special Issue on Asthma aims to provide the current knowledge on phenotypes and endotypes in appreciating and managing the heterogeneous condition that is asthma.
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Keywords
- acute severe asthma exacerbation
- Adhesion
- airway remodeling
- airway smooth muscle cell
- allergic airway inflammation
- alternative overlap syndrome
- alveolar macrophages
- anti-IL-5
- Asthma
- asthma-specific quality of life
- bronchial asthma
- bronchial biopsies
- bronchodilation
- Children
- chronic rhinitis
- clinical remission
- disease-specific quality of life
- eosinophil
- exacerbation
- FeNO
- health-related quality of Life (HRQLQ)
- hypercapnia
- hyperchloremic acidosis
- hypocapnia
- IL-1β
- Immune Regulation
- Immune responses
- Inflammation
- innate immunity
- interleukin-4
- interleukin-5 (IL-5)
- lactic acidosis
- longitudinal study
- lung function
- matrix metalloproteinases-9
- medicine
- microbiome
- mitochondrial function
- near fatal asthma
- NLRP3
- obstruction
- obstructive sleep apnea
- Pathogenesis
- PBMC
- Phenotype
- PreDicta
- preschool
- proliferation
- pulmonary fibroblast
- Reactive Oxygen Species
- reproducible
- Resistance
- severe asthma
- spirometry
- symptom persistence
- tissue inhibitor of metalloproteinase-1
- viability
- wheezing
Links
DOI: 10.3390/books978-3-03943-860-0Editions