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Molecular Psychiatry
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The book highlights important aspects of Molecular Psychiatry, including molecular mechanisms, animal models, biomarkers, advanced methods, drugs and antidepressant response, as well as genetics and epigenetics. Molecular mechanisms are a vital part of the search for the biological basis of psychiatric disorders, providing molecular hints that can later be tested as biomarkers or targets for drug development. Animal models represent a commonly used approach to aid in this bench-to-bed translation; the examples here are social defeat stress and the Roman High-Avoidance (RHA) and the Roman Low-Avoidance (RLA) rats. For biomarkers, psychiatric disorders pose a particular challenge due to the tissue specificity of many currently investigated biomarkers; i.e., not all blood-based measures directly represent changes in the brain. The Ebook includes five articles focused on the challenges of identifying clinically and biologically relevant biomarkers for psychiatric disorders. Scientific progress typically is fostered by the development of new methods. The application of machine learning methods for the proper analysis of Big Data and induced pluripotent stem cells are examples outlined in this Ebook. Furthermore, three articles are devoted to the understanding of the mechanisms of actions of existing drugs with the ultimate goal of identifying ways to predict treatment response in patients. Finally, three articles deepen the insight into the genetics and epigenetics of psychiatric disorders.
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Keywords
- (2R,6R)-Hydroxynorketamine
- 5-HT 4 receptor
- 5-HT4R
- acid sphingomyelinase
- actin dynamics
- affective temperament
- alcohol dependence
- alpha-Synuclein
- Alzheimer’s disease
- antidepressant
- antidepressant treatment
- antidepressants
- antipsychotics
- basic-helix-loop-helix
- BDNF
- Behavior
- biomarker discovery
- biomarkers
- Bipolar Disorder
- Brain
- Cardiovascular Disease
- Cell Adhesion Molecules
- Chemokines
- childhood-onset schizophrenia (COS)
- circadian rhythms
- coactivator
- Cognition
- copy number variation (CNV)
- cordance
- CRMP-2
- CyP40
- Cytoskeleton
- dendritic arborization
- Depression
- DISC1
- DNA Methylation
- dopaminergic gene polymorphisms
- DRR1
- Drug Design
- early neurodevelopment
- Electroconvulsive therapy
- endocrinology
- Expression
- FAM107A
- FKBP5
- FKBP51
- FKBP52
- forced swimming
- gender
- Gene expression
- general cognitive function
- genetic correlation
- Glucocorticoids
- GR
- GWAS
- Hamilton Scale of Depression
- Health systems & services
- Hippocampus
- HPA axis
- Hsp90
- Immune response
- immunohistochemistry
- immunology
- induced pluripotent stem cell (iPSC)
- Inflammation
- intelligence
- ketamine
- liver enzymes
- Machine learning
- major depression
- Major Depressive Disorder
- medicine
- Medicine: General Issues
- Mental health services
- mineralocorticoid receptor knockout
- miRNAs
- molecular chaperones
- mood disorder
- multi-target drugs
- multi-task learning
- n/a
- Nervous system
- neurodevelopment
- neuroinflammation
- neuronal differentiation
- Obesity
- parkinson’s disease
- polypharmacology
- PP5
- PPARγ
- Proteomics
- PSA-NCAM
- psychiatric disease
- Psychiatry
- rapid-acting
- resilience
- response variability
- Roman rat lines
- Schizophrenia
- Serotonin
- sex difference
- Sleep
- sleep EEG
- SNCA
- social defeat
- sphingolipid metabolism
- steroid hormones
- Stress
- stress physiology
- stress response
- susceptibility
- synapse
- T cells
- Th17 cells
- transcription biology
- Treg cells
- trkB
- TU3A
- Western Blot
- withdrawal
Links
DOI: 10.3390/books978-3-03936-121-2Editions