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T Cell Differentiation and Function in Tissue Inflammation
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Helper T cells play a critical role in the induction of tissue inflammation in immunity and autoimmunity. Various subsets of T cells such as Th1, Th2, Th9 and Th17 cells have been shown to play a key role in the induction of tissue inflammation in allergic and organ-specific autoimmune inflammation. On the other hand, regulatory cells such as Foxp3+Tregs and Tr1 cells are essential to control functions of effector T cells and maintain tissue homeostasis. Distinct transcriptional and molecular pathways have been identified for the generation of various effector and regulatory T cells. Emerging molecular signatures of these effectors and of regulatory T cells indicate plasticity in their developmental pathways, which is dictated by the tissue microenvironment and by other factors including cytokines and transcription factors.
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Keywords
- autoimmune disease
- Cancer
- CD4 T cell
- CD8 T cell
- Clinical & internal medicine
- Diseases & disorders
- immunology
- Inflammation
- medicine
Links
DOI: 10.3389/978-2-88963-614-3Editions