Feedback

X
Development of Humanized Mouse Models for Infectious Diseases and Cancer

Development of Humanized Mouse Models for Infectious Diseases and Cancer

0 Ungluers have Faved this Work
While the traditional animal models contributed immensely to biomedical research there remain many knowledge gaps in translating the results from these to humans. In this context, humanized mice transplanted with functional human cells in a physiological setting offer many advantages in deriving pre-clinical data more akin to that seen in the natural human host. There have been many recent advances in the field that encompass derivation of new transgenic breeds of immunodeficient mice harboring human cytokines and HLA alleles that permit improved human cell engraftment and differentiation. The ability to generate humanized mice with a functional immune system together with human tissue transplantation such as a functional liver has now paved the way for new experimentation not previously feasible and is beginning to shed light on the complex picture of human pathophysiology and immunopathogenesis. Specifically, human specific pathogens such as HIV, hepatitis viruses and malaria parasites are being studied in these systems and important data on pathogen life cycles in human cells in vivo, viral latency and human specific immune responses are being gathered. In the hematology front, new data are emerging on graft versus host disease using these models. Patient derived xenograft models endowed with transplanted human immune cells are permitting evaluations of various immunotherapies and identification of specific drugs for cancer therapy. Pathogenesis and immune responses for deadly pathogens, such as Ebola and newly emerged viruses like Zika are also being studied, adding a new twist and generating new knowledge in the context of human target cells in an in vivo setting.

This book is included in DOAB.

Why read this book? Have your say.

You must be logged in to comment.

Rights Information

Are you the author or publisher of this work? If so, you can claim it as yours by registering as an Unglue.it rights holder.

Downloads

This work has been downloaded 24 times via unglue.it ebook links.
  1. 8 - mobi (CC BY) at Unglue.it.
  2. 9 - epub (CC BY) at Unglue.it.
  3. 7 - pdf (CC BY) at Unglue.it.

Keywords

  • Clinical & internal medicine
  • Diseases & disorders
  • humanized mice for HIV
  • humanized mice in cancer research
  • humanized mice in infectious disease research
  • immunology
  • improved humanized mouse models
  • Malaria
  • medicine
  • new humanized mouse models
  • vaccines and therapeutics

Links

DOI: 10.3389/978-2-88963-481-1

Editions

edition cover

Share

Copy/paste this into your site: