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Preclinical Evaluation of Lipid-Based Nanosystems

Preclinical Evaluation of Lipid-Based Nanosystems

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The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)), nanoemulsions, and liposomes, among others, is widespread. Several researchers have described the advantages of different applications of these nanosystems. For instance, they can increase the targeting and bioavailability of drugs, improving therapeutic effects. Their use in the cosmetic field is also promising, owing to their moisturizing properties and ability to protect labile cosmetic actives. Thus, it is surprising that only a few lipid-based nanosystems have reached the market. This can be explained by the strict regulatory requirements of medicines and the occurrence of unexpected in vivo failure, which highlights the need to conduct more preclinical studies.Current research is focused on testing the in vitro, ex vivo, and in vivo efficacy of lipid-based nanosystems to predict their clinical performance. However, there is a lack of method validation, which compromises the comparison between different studies.This book brings together the latest research and reviews that report on in vitro, ex vivo, and in vivo preclinical studies using lipid-based nanosystems. Readers can find up-to-date information on the most common experiments performed to predict the clinical behavior of lipid-based nanosystems. A series of 15 research articles and a review are presented, with authors from 15 different countries, which demonstrates the universality of the investigations that have been carried out in this area.

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Keywords

  • acoustic response
  • alopecia areata
  • ammonia
  • atopic dermatitis
  • biocorona
  • biodistribution
  • Box‒Behnken design
  • Breast cancer
  • Caco-2 monolayer
  • Cancer
  • cholesterol
  • clarithromycin
  • colon cancer therapy
  • cyanocobalamin
  • D-optimal design
  • dexamethasone
  • dialysis
  • dissolution enhancement
  • docohexaenoic acid
  • DOE
  • doxorubicin
  • Drug delivery
  • drug release
  • efavirenz
  • ethyl cellulose
  • ex vivo permeation
  • fenofibrate
  • flaxseed oil
  • fluconazole
  • follicular targeting
  • formulation optimization
  • FZD10 protein
  • hyaluronic acid
  • hydrophobic ion pairing
  • intestinal permeation enhancers
  • intoxication
  • ligand distribution
  • light activation
  • lipid phase
  • lipid polymer hybrid nanocapsules
  • lipid vesicles
  • lipid-based formulation
  • lipolysis
  • lipomers
  • Liposome
  • liposomes
  • Melanoma
  • mesoporous silica
  • microbubble
  • mobility
  • N-alkylisatin
  • n/a
  • nanocarrier
  • nanoemulsion(s)
  • Nanomedicine
  • nanostructured lipid carriers
  • nanostructured lipid carriers (NLC)
  • nanotransfersome
  • nasal route
  • neuroinflammation
  • Neuroprotection
  • non-ionic surfactants
  • nose-to-brain
  • oligonucleotide
  • optimization
  • oral drug delivery
  • PAI-2
  • permeation
  • pharmacokinetics
  • phase-behavior
  • phospholipid coating
  • phospholipids
  • porous microparticles
  • psoriasis
  • quality by design (QbD)
  • rheological behavior
  • rivastigmine
  • self-emulsifying drug delivery systems
  • SerpinB2
  • silica-lipid hybrid
  • Skin
  • skin topical delivery
  • solid dosage forms
  • solid lipid nanoparticles
  • spray drying
  • Stability
  • supersaturation
  • target delivery nanosystem
  • Technology, engineering, agriculture
  • Technology: general issues
  • transferosomes
  • ulcer index
  • ultrasound contrast agents
  • urokinase plasminogen activator
  • vegetable oils
  • vitamin B12
  • zone of inhibition

Links

DOI: 10.3390/books978-3-0365-1549-6

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