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Immunohistochemical Expression
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Immunohistochemistry (IHC) is an ancillary method, widely used in pathologists’ practice, that allows identifying diagnostic and prognostic/predictive of therapeutic response protein markers on tissue samples by the use of specific monoclonal antibodies and chromogenic substances that guarantee the visualization of an antibody–antigene binding complex under a light microscope [1]. Coon et al., in 1941 [2], first introduced the use of fluorochrome-conjugated antibodies in clinical practice. Since then, IHC has gone from being a useful tool for identifying the differentiation line of otherwise undifferentiated cells to a technique capable of providing not only diagnostic but also prognostic and predictive indications of responses to specific therapeutic options [1,3]. The abovementioned peculiarities have made IHC one of the most used ancillary methods in the histopathological approach to human neoplastic and non-neoplastic diseases [3-5]. This Special Issue contains 11 accepted papers that provide readers with a comprehensive update on current and future applications of IHC in medical practice.
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Keywords
- ABCB5
- c-kit
- carcinogenesis
- chaperonopathies
- cytokeratin
- DEN
- Differential Diagnosis
- EGCG
- enteric nervous system
- excretion fraction of uric acid
- follicular adenoma
- follicular carcinoma
- Heart
- Hsp27
- Hsp60
- HSP70
- Hsp90
- human embryonal/fetal tissues
- hypouricemia
- immunohistochemistry
- Inflammation
- initial lymphatics
- Kidney
- Liver
- macroH2A
- matrix metalloproteinases
- medicine
- megacystis
- metastasis
- molecular chaperone
- n/a
- neoplastic tissue
- NGAL
- outcome and prognosis
- Oxidative Stress
- PDGFR
- Pericardium
- prognosis
- prognostic factor
- prostate cancer
- SLC22A12
- Temporomandibular joint
- temporomandibular joint disorder
- thyroid
- training exercise
- ultra-structural changes
- URAT1
- uric acid transporters
- urinary tract malformations
- uveal melanoma
- VDR
- Vitamin D
- WT1
Links
DOI: 10.3390/books978-3-0365-0401-8Editions