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The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy
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In this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the surrounding microenvironmental cells (e.g., macrophages, tumor-infiltrating lymphocytes and myeloid cells) and microenvironmental environments (e.g., oxidative stress, pH, hypoxia) and the implications of this dynamic interaction to tumor radioresistance, chemoresistance, invasion and metastasis. Finally, the importance and relevance of these findings are translated to cancer therapy.
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Keywords
- 3D co-culture
- biomarker
- biomarkers
- Bladder cancer
- Breast cancer
- Cancer
- cancer acidity
- cancer cells subpopulations
- cancer development
- cancer recurrence
- cancer stem cells
- cancer-associated fibroblast (CAF)
- carcinoma
- chemotherapy response
- clinical trials
- colon cancer
- cross-presentation
- CTLA-4
- cytokine/chemokine
- Darwinian evolution
- diclofenac
- evolutionary therapy
- extracellular matrix (ECM)
- feline mammary carcinoma
- glioblastoma (GB)
- glioma stem cells (GSC)
- Growth factors
- Head and Neck Cancer
- histone modification
- hyperosmolarity
- hypoxia
- Hypoxia Inducible Factor (HIF)
- immune cell infiltration
- immunomodulatory roles
- Immunotherapy
- inhibitor
- KDM5B
- koningic acid
- lung cancer
- Macrophages
- mammary gland
- medicine
- metastasis
- microenvironment
- molecular docking
- molecular subtypes of pancreatic cancer
- myeloid cells
- myeloid derived suppressor cells
- myeloid-derived suppressor cells
- Oxidative Stress
- PAI-1
- PAI-2
- Pancreatic Stellate Cells
- PD-1
- PD-L1
- plasmin
- plasminogen
- pre-metastatic niche
- preclinical modelling
- pro- and anti-tumor immune cells
- pro-inflammatory cytokines
- prognosis
- prostate cancer
- radioresistance
- radiosensitivity
- Radiotherapy
- radiotherapy dose fractionation
- Reactive Oxygen Species
- regulatory T cells
- repurposing
- Resistance
- S100A10
- S100A10 (p11)
- signaling pathways
- spheroid
- stroma
- syngeneic model
- targeted therapy
- therapeutic resistance
- TNF-α
- triple negative
- tumor growth
- Tumor microenvironment
- tumor progression
- tumor-associated macrophages
- tumour microenvironment
- uPA
- uPAR
Links
DOI: 10.3390/books978-3-0365-1607-3Editions