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Drug Absorption Studies: In Situ, In Vitro and In Silico Models
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This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs.
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Keywords
- acetaminophen-induced hepatotoxicity
- amorphous solid dispersion
- BCS drug classification
- bioavailability
- biomedical drug
- breast cancer resistance protein
- candesartan Cilexetil
- catabolism disorder
- chitosan
- cinnarizine
- D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS)
- dissolution profiles
- drug-phytochemical interaction
- Economics, finance, business & management
- Endocytosis
- enoxaparin
- enzyme
- extra virgin olive oil
- hepatic metabolism
- hydrogel
- in vivo–in vitro correlation
- Industry & industrial studies
- intestinal absorption
- intestinal permeability
- kinetics
- l-phenylalanine ammonia-lyase
- lipid-based drug delivery system
- lipid–polymer hybrid nanoparticles
- lipolysis
- lipolysis-permeation
- liver distribution
- LY335979
- Manufacturing industries
- medicine
- meloxicam
- Metabolism
- microsphere
- mixed inhibition
- naftidrofuryl oxalate
- Nanocrystals
- nasal administration
- non-sink condition
- oral
- oral mucositis
- P-Glycoprotein
- Permeability
- PermeaPad
- pH-modulation
- pharmaceutical availability
- Pharmaceutical industries
- phenolic compounds
- phenylketonuria
- poorly soluble drugs
- PVPK30
- quercetin
- rebamipide
- repaglinide
- secoiridoids
- silymarin
- solubility
- solubility–permeability interplay
- solubilizer additive
- spray drying
- spray-drying
- thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries
- thema EDItEUR::M Medicine and Nursing
- unstirred water layer
- WK-X-34
Links
DOI: 10.3390/books978-3-0365-2460-3Editions