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Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0
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This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor.
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Keywords
- 20-HETE
- active site access channels
- antibiotics
- arachidonic acid
- azole drugs
- Bacillus
- Bietti’s crystalline dystrophy
- biosynthetic gene clusters
- cavities boundaries
- circulatory CYPs
- comparative analysis
- Cryptococcus
- Cryptococcus neoformans
- Crystal structure
- Cyanobacteria
- CYP diversity analysis
- CYP128A1
- CYP139A1
- CYP2C8
- CYP3A4
- CYP4 genes
- CYP450
- CYP51
- Cytochrome b5 (CYB5)
- Cytochrome P450
- cytochrome P450 monooxygenase
- cytochrome P450 monooxygenases
- cytochrome P450 monooxygenenases
- cytochrome P450 reductase
- cytochromes P450
- cytochromes P450 monooxygenases
- drug metabolism
- electron transfer
- electron-transfer (ET)
- enzyme substrate specificity
- Exosomes
- extracellular vesicles
- extrahepatic tissues
- fatty acid
- Fungal pathogens
- gene-cluster diversity percentage
- genetic polymorphisms
- genome data mining
- genome data-mining
- host metabolism
- human pathogens
- isoform
- lamellar ichthyosis
- mathematical formula
- mechanism-based inhibitor
- membrane protein
- menaquinone
- Metabolism
- microsomal cytochrome P450 (CYP)
- minimal cost paths
- Molecular dynamic simulations
- molecular dynamics simulation
- molecular functionality
- mutagenesis
- Mycobacterium
- Mycobacterium tuberculosis
- Mycobacterium tuberculosis H37Rv
- NADPH-cytochrome P450 reductase (CPR)
- non-ribosomal peptides
- P450 blooming
- P450 diversity percentage
- P450 profiling
- paclitaxel
- phylogenetic analysis
- Plasma
- polyketides
- polymorphisms
- precision Cardio-Oncology
- precision medicine
- protein dynamics
- protein-membrane interactions
- protein–protein interaction
- Reactive Oxygen Species
- Reference, information & interdisciplinary subjects
- Research & information: general
- RNA interference
- secondary metabolites
- SNPs
- Sogatella furcifera
- Streptomyces
- sulfoxaflor
- Systems Medicine
- terpenes
- transcriptome
- tremellomycetes
- trichosporon
- Tuberculosis
Links
DOI: 10.3390/books978-3-0365-0257-1Editions