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Marine Compounds and Cancer 2020

Marine Compounds and Cancer 2020

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The very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-U®), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development.

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Keywords

  • 12-deacetyl-12-epi-scalaradial
  • 3-alkylpyridinium polymers
  • A375 and HeLa cell lines
  • A549 cells
  • ABC transporter
  • actinomycin
  • AD0157
  • adriamycin resistance
  • Aeroplysinin
  • Akt
  • Angiogenesis
  • angiogenesis inhibitor
  • ansamycins
  • anthranilic acid
  • anti-angiogenesis
  • anti-angiogenic
  • anti-cancer
  • anti-metastatic activity
  • anti-proliferation
  • anti-proliferative
  • antiangiogenesis
  • antiangiogenic
  • antibacterial
  • Antibody Drug Conjugates (ADCs)
  • anticancer
  • anticancer activity
  • anticancer agent
  • anticancer immunity
  • anticarcinogenic
  • anticoagulant
  • anticoagulation
  • antifouling
  • antimicrobial peptide (AMP)
  • antioxidant
  • antiproliferative
  • antiproliferative activity
  • antitumor
  • antitumor activities
  • antitumoral
  • antitumour
  • AP-1
  • Apoptosis
  • apoptosis-inducing activity
  • approved antitumor agents
  • araguspongine C
  • arrest of cell cycle
  • Aspergillus
  • Autophagy
  • autophagy inducers
  • autophagy inhibitors
  • azoxymethane
  • BCRP/ABCG2
  • BEL-7402 cell
  • benzo[a]pyrene
  • bioactive natural product
  • bioanalysis
  • bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM)
  • bonnethead shark
  • Breast cancer
  • breast cancer cells
  • Brevianamide
  • brominated indoles
  • bromophenol
  • buccal gland
  • c-JUN
  • c-Met
  • C15 acetogenins
  • camptothecin
  • Cancer
  • cancer genes
  • cancer preventive
  • cancer progression
  • Cantabrian Sea-derived actinobacteria
  • carbocyclic analogue
  • carcinoembryonic antigen
  • Caribbean sponge
  • carotenoid
  • carotenoids
  • caspase cascade
  • Cell Adhesion
  • Cell Adhesion Molecules
  • Cell Cycle
  • cell cycle arrest
  • cell migration
  • cembranoids
  • chemical conjugation
  • chemoprevention
  • chemopreventive
  • chemosensitization
  • chemotherapy
  • chimera
  • CHOP
  • chromatography
  • circulating tumor cells
  • cisplatin
  • clinical trials
  • colorectal cancer
  • cooperative binding
  • Cyclin D1
  • cyclin-dependent kinase
  • CYP1A1
  • cystatin F
  • cystatin superfamily
  • cytokine release
  • Cytoskeleton
  • cytotoxic activity
  • Cytotoxicity
  • deep-sea
  • depolymerisation
  • dibromotyrosine
  • dieckol
  • divergolides
  • DNA minor groove binder
  • Drug Discovery
  • Ecklonia cava
  • elisidepsin
  • EMT
  • endoperoxide
  • Endophytic fungus
  • endothelial cells
  • energy stress
  • epigonal organ
  • epithelial–mesenchymal transition
  • ER-stress
  • ET-743
  • Evolution
  • FAK
  • fascaplysin
  • fatty acid 2-hydroxylase
  • Fatty acids
  • FAU
  • FBDD
  • fucoidan
  • fucoxanthin
  • fumigaclavine C
  • gemcitabine
  • Gene expression
  • Glioblastoma
  • gliotoxin
  • glucocorticoid receptor
  • glycosaminoglycans
  • gorgonian
  • Haliclona gracilis
  • HeLa cells
  • heparan sulphate
  • Heparanase
  • hepatocellular carcinoma
  • HER2
  • HIF-1
  • hippuristanol
  • Hsp90
  • human lung cancer
  • human normal diploid fibroblast (TIG-1 cells)
  • human sarcoma cell line (HT1080 cells)
  • humulane sesquiterpenoids
  • Hybridization
  • hydroxylated lipids
  • hypoxia
  • hypoxia-inducible factor-1
  • IL-6
  • in vivo model
  • Inflammation
  • inhibitor
  • integrin β1
  • Invasion
  • isatin
  • Isofistularin
  • itampolin A
  • Jaspine B
  • JNK1/2
  • Jurkat
  • kalkitoxin
  • kunitz type inhibitor
  • Lampetra morii
  • Leathesia nana
  • Leptogorgia
  • Leukemia
  • lipid rafts
  • low molecular weight fucoidan extract
  • low toxic
  • LS-1
  • lung cancer
  • lung metastasis
  • Lyngbya majuscula
  • macrolide
  • mangrove-derived actinomycete
  • manzamine A
  • MAPK/ERK pathway
  • marangucyclines
  • marine antitumor agents
  • marine biotechnology
  • marine compound
  • marine drug
  • marine drugs
  • marine fungus
  • marine metabolites
  • marine mollusc
  • Marine Natural Products
  • marine organisms
  • marine sponges
  • marine-derived drugs
  • Marthasterias glacialis L.
  • MCP-1
  • mechanisms of action
  • medicine
  • Melanoma
  • membrane permeabilization
  • metastasis
  • Microalgae
  • Micromonospora
  • migration
  • Mitochondria
  • mitochondria toxin
  • mitochondrial pathway
  • Mitochondrial dysfunction
  • molecular docking
  • molecular mechanisms
  • molecular modeling
  • molecular oncology
  • Moorea producens
  • MRP1/ABCC1
  • multi-drug resistant leukemia
  • multidrug resistance
  • Mycalin A
  • Mycochromenic acid derivative
  • N-Ras
  • n/a
  • nanoparticle
  • naphthopyrones
  • natural marine compounds
  • natural product
  • Natural Products
  • neuroblastoma-rat sarcoma
  • NF-κB
  • NF-κB signaling
  • Nicotine
  • nicotinic acetylcholine receptor
  • Non-Small Cell Lung Cancer
  • non-small cell lung cancer (NSCLC)
  • non-small cell lung carcinoma
  • nonfunctioning pituitary adenomas
  • novel inhibitor
  • NSCLC
  • Nur77
  • Osteosarcoma
  • oxidative stress
  • Oxidative Stress
  • P-gp/ABCB1
  • P2X7 receptor
  • p38
  • p38/ERK
  • p38α
  • p65
  • pachastrissamine
  • palmitic acid
  • paulomycins
  • pazopanib
  • PEL
  • Penicillium brevicompactum
  • Penicillium paneum
  • phase I
  • pheochromocytoma and paraganglioma
  • phlorotannins
  • phycocyanin
  • PI3K/AKT
  • plakortide
  • plitidepsin
  • Pollution
  • poly(ADP-ribose)-polymerase inhibitor
  • polyoxygenated steroids
  • Polyphenols
  • polysaccharides
  • Porifera
  • porifera/sponge
  • preclinical
  • programmed cell death
  • programmed cell death-ligand 1
  • programmed cell death-ligand 2
  • proliferation
  • prostate cancer
  • proteasomal degradation
  • proteomic
  • pseudopterosin
  • puupehenones
  • pyrrolidinedione
  • Reactive Oxygen Species
  • RGD motif
  • ribosomal protein genes
  • ROS
  • RPS30
  • Safety
  • Sarcophyton ehrenbergi
  • sea anemone
  • Sea Cucumbers
  • seaweed
  • secondary metabolites
  • sediment
  • selenium-containing polysaccharide-protein complex
  • Sepia ink polysaccharides
  • shrimp
  • signal transduction
  • sinulariolide
  • sipholenol A
  • small cell lung cancer
  • SNORA62
  • snoRNA
  • SNU-C5/5-FU
  • soft coral
  • soft tissue sarcoma
  • Soft Tissue Sarcoma
  • sphingosine kinase inhibitor
  • sponge
  • Sponges
  • STAT3
  • Streptomyces sp. SCSIO 11594
  • synergism
  • synthetic analogues
  • SZ-685C
  • targeted therapy
  • terpenes
  • tetracenomycin X
  • TGF-β signaling
  • Thalassia testudinum
  • thalassiolin B
  • therapeutic compounds
  • Tilapia piscidin 4 (TP4)
  • TNFα
  • Topo I inhibitor
  • topoisomerase
  • trabectedin
  • triterpene glycosides
  • TRPM7
  • tumor cell line
  • Tumor microenvironment
  • tumor-associated macrophages
  • Ulva fasciata
  • uveal melanoma
  • VEGF
  • virtual screening
  • xyloketal B
  • α9-nicotinic acetylcholine receptors (nAChRs)
  • αO-conotoxin GeXIVA
  • β1-integrin
  • λ-carrageenan

Links

DOI: 10.3390/books978-3-0365-0631-9

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