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O-GlcNAcylation and Cancer
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This book gathers reviews and articles on the role of O-GlcNAcylation in cancer underlying the pharmacological targeting of the O-GlcNAcylation enzymes OGT and OGA as a promising anticancer strategy. Particular attention is paid to the involvement of O-GlcNAcylation in the regulation of transcription and as a link between nutrition and epigenetic dynamics or cellular energy metabolism. The role of O-GlcNAcylation in metastasis, immune responses, and resistance to chemotherapeutic agents is also discussed.
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Keywords
- Breast cancer
- Cancer
- cellular stress
- colon cancer
- Energy Metabolism
- epigenetics
- EZH2
- Glucose
- immune surveillance
- invasiveness
- lung adenocarcinoma
- Mitochondria
- mOGT
- Nutrition
- O-GlcNAc
- O-GlcNAc transferase
- O-GlcNAcase
- O-GlcNAcylation
- OGT
- Reference, information & interdisciplinary subjects
- Research & information: general
- SAM68
- thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
- transcription
- UNC5A
Links
DOI: 10.3390/books978-3-0365-3082-6Editions