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Special Issue in Honor of Professor James D. McChesney on the Occasion of his 80th Birthday
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Plants have been the sources of important pharmaceuticals, flavoring agents, and agrochemicals. The antimalarial drugs artemisinin and quinine; the anticancer drugs taxol, etoposide, and vinca alkaloids; the sugar-free sweetening agents stevioside and rebaudiosides; and antifeedant azadiractin are good examples of important plant-based drugs, food additives, and agrochemicals currently on the market. Despite these and many other successes, there are significant challenges to discovering and developing commercially important natural products from plants, such as procuring plant materials in large quantities, separating active constituents from complex mixtures, and undesirable qualities, such as low solubility or poor chemical or metabolic stability of active constituents. Dr. James D. McChesney has contributed immensely to overcoming the inherent challenges associated with discovering and developing products modeled from plant-based natural product leads. His research on artemisinin, taxol, galanthamine, podophyllotoxin, and stevia sweet glycosides exemplifies the magnitude of these contributions. His extensive work on the structural modification of taxol led to the discovery and development of the anticancer agent TPI 287, a third-generation taxane analog that is currently undergoing clinical trials. Dr. McChesney has had a long, distinguished teaching and research career, has authored more than 225 research publications, and holds more than 60 patents. He is a past president and Fellow of the American Society of Pharmacognosy and a Fellow of the AAAS. He has mentored many graduate students, post-docs, and junior faculty members who hold prominent positions in natural products research establishments in the US and worldwide. We wish to dedicate this Special Issue Book Version to celebrate the eightieth birthday of Dr. McChesney, a prolific thinker with abundant inventiveness in the field of natural product chemistry and pharmacognosy.
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Keywords
- 1-decanol
- 1-octanol
- 3-monochloropropane-1,2-diol esters
- 5-epi-machaerifurogerol
- anti-inflammatory activity
- Artocarpus lakoocha
- Atractylodes macrocephala
- atractylon derivatives
- autodocking
- avocado oil
- Biology, Life Sciences
- biopesticides
- botanical sources
- Botryosphaeria dothidea
- Calu-3 cell line
- Cancer
- cancer chemotherapy
- charantoside XV
- cucurbitane-type triterpene glycosides
- deterrent
- DNA damaging
- drug resistance
- endocyclic and exocyclic diterpene glycosides
- Endophytic fungus
- enzyme kinetics
- Ethiopia
- fatty acid
- flavonoid
- GC-FID
- GC-MS
- GC/MS
- glycerin
- glycidyl esters
- glycyrrhizin
- gram negative bacteria
- HPLC methods
- HPTLC
- in silico study
- in vitro propagation
- inhibition activity
- isoflavonoid
- isoflavonoids
- isolation and identification
- larvicidal activity
- machaeridiol A–C
- machaerifurogerol
- machaeriol A–C
- Machaerium Rimachi 12161
- Magnoliaceae
- Malaria
- mass spectrometry dissociation pattern
- Mathematics & science
- medicinal crops
- Medicinal plants
- molecular docking
- Momordica charantia
- monoamine oxidase-B
- mosquito control
- MRSA
- n/a
- naphtho-γ-pyrones
- neurological disorder
- nigerasperone A
- NMR
- oxyresveratrol
- Persea americana Mill.
- phytochemistry
- phytomedicines
- phytotoxin
- plant pathogenic fungi
- poly(ethylene glycol)
- poly(ε-caprolactone)
- polyisoprenylated benzophenones
- pro-oxidant
- process contaminants
- processing
- propolis
- quality evaluation
- recombinant monoamine oxidase-A
- Reference, information & interdisciplinary subjects
- Research & information: general
- SARS-CoV-2
- scale up
- Stevia rebaudiana
- surface plasmon resonance
- teratopyrones
- Teratosphaeria
- Torreya taxifolia
- triglyceride
- UHPLC/ESI-MS
- UHPLC/Q-TOF-MS analysis
- VRE
- wheat bran
- α-amylase
- α-glucosidase
- γ-lactam alkaloids
Links
DOI: 10.3390/books978-3-0365-2713-0Editions