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Novel Antibacterial Agents
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This book was devoted to the latest advances achieved in the antibacterial field, with a focus on the recent efforts made to develop new antimicrobial agents with novel modes of action, and a perspective on future directions of this line of research. Antimicrobial resistance has become a major threat to global health, and the twenty-two published articles here reported put in evidence that the discovery and development of new antibiotics are extremely challenging. The antimicrobial research covers a wide area, spanning from the design of new compounds, also supported by molecular modeling techniques, their synthesis and characterization, and biological tests.In this context, the current crisis caused by the COVID-19 pandemic, but also older threats, such as the human immunodeficiency virus or the hepatitis C virus, require greater attention than ever.The research works described in this book provide an extremely useful example of the results achieved in the field of antibacterial drug development. The search for new chemical entities was approached starting from both natural and synthetic compounds and addressing different targets. In addition, recent findings were presented and discussed highlighting the strategies to fight bacterial resistance. Detailed references to the state-of-the-art can be found in this book.We strongly encourage the wide group of readers to explore the book that we are presenting, to get inspired to develop new approaches for the diagnosis and treatment of antibacterial diseases, and to circumvent resistance issues.
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Keywords
- 1,3,4-thiadiazole
- 3-pentadecylcatechol
- 3-pentylcatechol
- 3D-printing
- Abies alba M.
- Acinetobacter baumannii
- adjuvants agents
- aggregation
- alternative infection models
- Amino acid
- amitriptyline analogues
- AMP
- anti-cyanobacterial properties
- Anti-Infective Agents
- antibacterial
- antibacterial action
- Antibacterial activity
- antibacterial agent
- Antibacterial Agents
- antibacterial properties
- antibiofilm activity
- antibiotic resistance
- antibiotic-resistance
- anticancer
- antifungal activity
- antileishmanial agents
- antimicrobial
- antimicrobial activity
- antimicrobial peptide
- antimicrobial screening
- antioxidant activity
- antioxidant capacity
- antiviral activity
- atopic dermatitis
- bacteriocin
- biofilm inhibition and eradication
- bioisosterism
- biological activities
- biomembranes
- Biophysics
- carbon nanotubes
- chemical investigation
- coating
- compounds screening
- computer-aided prediction
- covalent inhibitor
- COVID-19
- cutaneous dysbiosis
- cyclobutenaminone
- CYP 51
- dental polymer
- diarrhea
- disinfectant
- docking
- Drug delivery systems
- Drug Design
- drug resistance
- ESKAPE
- essential oil
- essential oils
- extract
- furan
- GC-MS
- H7PX glioma cells
- Helicobacter pylori
- HS-GC/MS
- hyperbranched dendritic polymers
- imidazole and imidazolium salts
- indole
- indole derivatives
- irreversible
- Lactobacillus plantarum
- Leishmania tropica and infantum
- LIBS
- lipophilicity
- lucanthone analogues
- lytic infection
- magistral phage
- marine bisindole alkaloids
- Medicinal plants
- mesoporous silica nanoparticles
- methicillin-resistant Staphylococcus aureus
- microbial therapy
- molecular docking
- Molecular Dynamics
- molecular modelling studies
- Moringa oleifera
- MRSA
- Mur B
- MurA
- Mycobacterium tuberculosis
- mycobactins
- n/a
- Natural Products
- NMR
- oral administration
- Origanum majorana
- overcoming of drug resistance
- Oxidative Stress
- phage production
- Picea abies L.
- Pinus cembra L.
- Pinus mugo Turra
- plant compounds
- plantaricin
- polydimethylsiloxane
- Pseudomonas aeruginosa
- pulmonary delivery
- quaternary ammonium groups
- quinolizidine-derived compounds
- quorum sensing inhibition
- Reference, information & interdisciplinary subjects
- Research & information: general
- Rosmarinus officinalis
- saccharin
- seed extract
- selectivity
- sequence alignment
- siderophores
- skin barrier
- Staphylococcus aureus
- tetrazole
- thioxothiazolidine
- Thymus mastichina
- Thymus zygis
- topical delivery
- triple therapy
- tris(1H-indol-3-yl)methylium
- Tuberculosis
- turbomycin
- urushiol
- VBNC cells
Links
DOI: 10.3390/books978-3-0365-2860-1Editions