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Identification and Characterization of Genetic Components in Autism Spectrum Disorders 2019
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The Identification of the Genetic Components of Autism Spectrum Disorders 2019 will serve as a resource for laboratory and clinical scientists as well as translational-based researchers, primary healthcare providers or physicians, psychologists/psychiatrists, neurologists, developmental pediatricians, clinical geneticists, and other healthcare providers, teachers, caregivers and students involved in autism spectrum disorders (ASD) with the goal to translate information directly to the clinic, education and home setting. Other professionals, students and families might find this textbook of value based on better awareness, causes and understanding of genetic components leading to autism and open avenues for treatment. Genetics play a role with up to 90% of autism, with over 800 currently recognized genes contributing to causes, clinical presentation, treatment, and counseling of family members. This textbook includes 13 chapters divided into three sections (clinical, genetics, other) written by experts in the field dedicated to research and clinical care, description, treatment and generating relevant reviews for ASD and related disorders impacting gene expression, profiling, and pathways. Identification of potential risk factors will be discussed, including obesity, microbiota, malignancy, and the immune system, as well as their direct or indirect contribution to ASD treatment and causation.
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Keywords
- 15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndrome
- 15q11.2 BP1–BP2 microdeletion (Burnside–Butler syndrome)
- AMPA receptors
- AmplideX
- animal model
- ASD
- Autism
- autism candidate genes
- Autism Spectrum Disorder
- Autism Spectrum Disorders
- Autism spectrum disorders (ASD)
- biological networks
- Biology, Life Sciences
- BMI
- body mass index
- Cancer
- case-control association analysis
- collapsin response mediator protein 4
- CYFIP1
- cytokine
- data integration
- developmental delays
- DNA Methylation
- epigenetics
- expression profile
- Fragile X Syndrome
- Gene expression
- Genetics
- Genetics (non-medical)
- Genomics
- guanine nucleotide exchange factor
- gut
- gut–brain interaction
- heterogeneity reduction
- IL-6
- imprinting
- Intellectual Disability
- leaky gut
- Life sciences: general issues
- magnesium transporters and supplementation
- maternal immune activation
- Mathematics & science
- Mice
- microbiome
- microRNA- interactions
- molecular functions and processes
- monocyte
- mosaicism
- motor delays
- MS-QMA
- multi-omics
- NanoString
- network diffusion
- neurodevelopmental disorder
- NIPA1
- NIPA2
- NMDA receptors
- Obesity
- overlapping genes and gene profiling
- overweight
- parent-of-origin effects
- Pediatrics
- Phelan McDermid Syndrome
- phenotype-genotype correlation
- phenotypes and diseases
- postnatal VPA injection
- potential treatment options
- Prader–Willi and Angelman syndromes
- ProSAP2
- quantitative traits
- Reference, information & interdisciplinary subjects
- Research & information: general
- RNA toxicity
- sam
- sex different phenotypes
- Shank
- stratification by trait severity
- STRING-protein-protein interaction
- super-pathways
- synaptic plasticity
- synaptotagmin-like protein 4 (SYTL4)
- SYTL4-protein structure
- T cell cytokine
- trained immunity
- transmembrane protein 187 (TMEM187)
- TUBGCP5 genes
- whole-exome sequencing
- β-glucan
Links
DOI: 10.3390/books978-3-0365-3610-1Editions